AMFR 抗体
Quick Overview for AMFR 抗体 (ABIN7111885)
抗原
See all AMFR 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- AMFR antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- autocrine motility factor receptor
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亚型
- IgG
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anti-Autocrine Motility Factor Receptor (AMFR) (AA 456-643) antibody
AMFR 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Autocrine Motility Factor Receptor (AMFR) (AA 571-601) antibodyAMFR 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Autocrine Motility Factor Receptor (AMFR) (AA 571-601) antibodyAMFR 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB4403-4404 unconjugated
anti-Autocrine Motility Factor Receptor (AMFR) (AA 456-639) antibodyAMFR 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Autocrine Motility Factor Receptor (AMFR) (AA 485-643) antibodyAMFR 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Autocrine Motility Factor Receptor (AMFR) (C-Term) antibodyAMFR 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Autocrine Motility Factor Receptor (AMFR) (AA 384-643) antibodyAMFR 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Autocrine Motility Factor Receptor (AMFR) (AA 371-400) antibodyAMFR 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Autocrine Motility Factor Receptor (AMFR) (AA 451-550) antibodyAMFR 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3D9 unconjugated
anti-Autocrine Motility Factor Receptor (AMFR) (AA 110-159) antibodyAMFR 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔, Bat, 小鸡, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:5000, IF: 1:10-1:100, IHC: 1:20-1:200, IP: 1:200-1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- AMFR (Autocrine Motility Factor Receptor (AMFR))
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别名
- AMFR
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背景
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Synonyms: E3 ubiquitin-protein ligase AMFR|Autocrine motility factor receptor (AMF receptor)|RING finger protein 45|gp78|AMFR|RNF45
Background: E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation(ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor.
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分子量
- 73 kDa
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基因ID
- 267
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UniProt
- Q9UKV5
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途径
- ER-Nucleus Signaling
抗原
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