ATR 抗体
Quick Overview for ATR 抗体 (ABIN7111876)
抗原
See all ATR 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- ATR antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- ataxia telangiectasia and Rad3 related
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亚型
- IgG
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anti-ATR serine/threonine kinase (ATR) (pThr1989) antibody
ATR 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-ATR serine/threonine kinase (ATR) (AA 366-550) antibodyATR 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 3G6D2 unconjugated
anti-ATR serine/threonine kinase (ATR) (AA 2545-2645) antibodyATR 适用: 人 ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal 1E9 unconjugated
anti-ATR serine/threonine kinase (ATR) (AA 2545-2644) antibodyATR 适用: 人 ELISA, WB, IF 宿主: 小鼠 Monoclonal 3F2 unconjugated
anti-ATR serine/threonine kinase (ATR) (AA 2405-2644) antibodyATR 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-ATR serine/threonine kinase (ATR) (pSer428) antibodyATR 适用: 人, 小鼠, 大鼠 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-ATR serine/threonine kinase (ATR) (AA 2545-2644) antibodyATR 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
anti-ATR serine/threonine kinase (ATR) (pSer428) antibodyATR 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-ATR serine/threonine kinase (ATR) antibodyATR 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-ATR serine/threonine kinase (ATR) (Ser16) antibodyATR 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:300-1:1000, IP: 1:200-1:1000, IHC: 1:50-1:500, IF: 1:50-1:500
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- ATR (ATR serine/threonine kinase (ATR))
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别名
- ATR
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背景
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Synonyms: Serine/threonine-protein kinase ATR|Ataxia telangiectasia and Rad3-related protein|FRAP-related protein 1|ATR|FRP1
Background: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation(IR), ultraviolet light(UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.
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分子量
- 250-290 kDa
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基因ID
- 545
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UniProt
- Q13535
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途径
- Positive Regulation of Response to DNA Damage Stimulus
抗原
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