Ataxin 2 抗体
Quick Overview for Ataxin 2 抗体 (ABIN7111771)
抗原
See all Ataxin 2 (ATXN2) 抗体适用
宿主
克隆类型
标记
应用范围
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- ataxin 2
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亚型
- IgG
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anti-Ataxin 2 (ATXN2) (C-Term) antibody
ATXN2 适用: 人, 小鼠, 大鼠 WB, IF, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Ataxin 2 (ATXN2) (AA 775-856) antibodyATXN2 适用: 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Ataxin 2 (ATXN2) (Internal Region) antibodyVerified ATXN2 适用: 人 ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Ataxin 2 (ATXN2) (AA 1283-1313), (C-Term) antibodyATXN2 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ataxin 2 (ATXN2) (AA 174-383) antibodyATXN2 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Ataxin 2 (ATXN2) (Internal Region) antibodyATXN2 适用: 人 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ataxin 2 (ATXN2) (AA 321-355) antibodyATXN2 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB53600 unconjugated
anti-Ataxin 2 (ATXN2) (AA 725-757) antibodyATXN2 适用: 人 WB 宿主: 兔 Polyclonal RB53601 unconjugated
anti-Ataxin 2 (ATXN2) (AA 1214-1313) antibodyATXN2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Ataxin 2 (ATXN2) (Middle Region) antibodyATXN2 适用: 人, 小鼠, Cow, 犬 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:1000-1:4000, IP: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:10-1:100
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
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有效期
- 12 months
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- Ataxin 2 (ATXN2)
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别名
- Ataxin 2
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背景
- Synonyms:ataxin 2, ATX2, ATXN2, SCA2, TNRC13 Background:This gene belongs to a group of genes that is associated with microsatellite-expansion diseases, a class of neurological and neuromuscular disorders caused by expansion of short stretches of repetitive DNA. The protein encoded by this gene has two globular domains near the N-terminus, one of which contains a clathrin-mediated trans-Golgi signal and an endoplasmic reticulum exit signal. The encoded cytoplasmic protein localizes to the endoplasmic reticulum and plasma membrane, is involved in endocytosis, and modulates mTOR signals, modifying ribosomal translation and mitochondrial function. The N-terminal region of the protein contains a polyglutamine tract of 14-31 residues that can be expanded in the pathogenic state to 32-200 residues. Intermediate length expansions of this tract increase susceptibility to amyotrophic lateral sclerosis, while long expansions of this tract result in spinocerebellar ataxia-2, an autosomal-dominantly inherited, neurodegenerative disorder. Genome-wide association studies indicate that loss-of-function mutations in this gene may be associated with susceptibility to type I diabetes, obesity and hypertension. Alternative splicing results in multiple transcript variants.
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分子量
- 140-150 kDa
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基因ID
- 6311
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UniProt
- Q99700
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途径
- Ribonucleoprotein Complex Subunit Organization
抗原
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