APOBEC3G 抗体
Quick Overview for APOBEC3G 抗体 (ABIN7111664)
抗原
See all APOBEC3G 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- APOBEC3G antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
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亚型
- IgG
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应用备注
- WB: 1:200-1:1000, IHC: 1:20-1:200, IF: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- APOBEC3G (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3G (APOBEC3G))
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别名
- APOBEC3G
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背景
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Synonyms: DNA dC->dU-editing enzyme APOBEC-3G|APOBEC-related cytidine deaminase (APOBEC-related protein, ARCD)|APOBEC-related protein 9 (ARP-9)|CEM-15 (CEM15)|Deoxycytidine deaminase (A3G)|APOBEC3G
Background: DNA deaminase(cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and-independent mechanisms. Exhibits potent antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity also against simian immunodeficiency viruses(SIVs), hepatitis B virus(HBV), equine infectious anemia virus(EIAV), xenotropic MuLV-related virus(XMRV) and simian foamy virus(SFV). May inhibit the mobility of LTR and non-LTR retrotransposons.
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分子量
- 46 kDa
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基因ID
- 60489
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UniProt
- Q9HC16
抗原
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