DNMT3A 抗体 (pSer390, pSer393) (HRP)
Quick Overview for DNMT3A 抗体 (pSer390, pSer393) (HRP) (ABIN7091877)
抗原
See all DNMT3A 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer390, pSer393
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交叉反应
- 人
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated Synthesised phosphopeptide derived from human Dnmt3a around the phosphorylation site of Ser390 + Ser393
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亚型
- IgG
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应用备注
- WB 1:300-5000
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限制
- 仅限研究用
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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- DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))
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别名
- Dnmt3a
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背景
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Synonyms: Dnmt3a (phospho S390 + S393), Dnmt3a (phospho Ser390 + Ser393), p-Dnmt3a (phospho S390 + S393), DNA (cytosine 5) methyltransferase 3 alpha, DNA (cytosine 5) methyltransferase 3A, DNA (cytosine-5)-methyltransferase 3A, DNA cytosine methyltransferase 3A2, DNA methyltransferase 3a, DNA methyltransferase HsaIIIA, DNA MTase HsaIIIA, DNM3A_HUMAN, DNMT 3a, DNMT, Dnmt3a, DNMT3A2, M.HsaIIIA, MCMT, OTTHUMP00000201149.
Background: Required for genome wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity.
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基因ID
- 1788
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UniProt
- Q9Y6K1
抗原
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