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PDIA2 抗体 (AA 431-525)

PDIA2 适用: 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN705881
发货至: 中国
  • 抗原 See all PDIA2 抗体
    PDIA2 (Protein Disulfide Isomerase Family A, Member 2 (PDIA2))
    抗原表位
    • 14
    • 7
    • 7
    • 6
    • 6
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 431-525
    适用
    • 34
    • 27
    • 20
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    小鼠, 大鼠
    宿主
    • 52
    • 4
    • 1
    克隆类型
    • 55
    • 2
    多克隆
    标记
    • 21
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This PDIA2 antibody is un-conjugated
    应用范围
    • 45
    • 26
    • 12
    • 12
    • 11
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    交叉反应
    小鼠, 大鼠
    预测反应
    Human
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human PDIA2
    亚型
    IgG
    Top Product
    Discover our top product PDIA2 Primary Antibody
  • 应用备注
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    有效期
    12 months
  • 抗原
    PDIA2 (Protein Disulfide Isomerase Family A, Member 2 (PDIA2))
    别名
    PDIA2 (PDIA2 产品)
    别名
    PDIA2 antibody, DKFZp468D2220 antibody, 1810041F13Rik antibody, AI661267 antibody, Pdip antibody, Pdipl antibody, PDA2 antibody, PDI antibody, PDIP antibody, PDIR antibody, protein disulfide isomerase family A member 2 antibody, protein disulfide isomerase associated 2 antibody, protein disulfide isomerase family A, member 2 antibody, PDIA2 antibody, Pdia2 antibody
    背景

    Synonyms: Pancreatic protein disulfide isomerase, PDA2, PDI, PDIA2, PDIP, Protein disulfide isomerase A2, Protein disulfide isomerase, Protein disulfide isomerase family A member 2, PDIA2_HUMAN.

    Background: The three dimensional structure of many extracellular proteins is stabilized by the formation of disulphide bonds. Studies suggest that a microsomal enzyme known as Protein Disulphide Isomerase (PDI) is involved in disulphide-bond formation and isomerization, as well as the reduction of disulphide bonds in proteins. PDI, which catalyses disulphide interchange between thiols and protein dilsulphides, has also been referred to as thiol:protein-disulphide oxidoreductase and as glutathione:insulin transhydrogenase because of its role in reduction of disulphide bonds. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the carboxy-terminus of PDI and other soluble endoplasmic reticulum (ER) resident proteins including the 78 and 94 kDa glucose regulated proteins (GRP78 and GRP94 respectively). The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.

    基因ID
    64714
    途径
    Maintenance of Protein Location, Cell RedoxHomeostasis, Unfolded Protein Response
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