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- 抗原 See all TBC1D7 抗体
- TBC1D7 (TBC1 Domain Family, Member 7 (TBC1D7))
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This TBC1D7 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 交叉反应
- 人, 大鼠
- 纯化方法
- Affinity purification
- 免疫原
- Recombinant protein corresponding to Mouse TBC1D7
- Top Product
- Discover our top product TBC1D7 Primary Antibody
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anti-TBC1 Domain Family, Member 7 (TBC1D7) (AA 1-293) antibody
TBC1D7 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-TBC1 Domain Family, Member 7 (TBC1D7) (AA 1-293) antibodyTBC1D7 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-TBC1 Domain Family, Member 7 (TBC1D7) (AA 154-203) antibodyTBC1D7 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB (H,M,R) 1: 500- 1: 1000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS, pH 7.4, 0.02 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
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- 抗原
- TBC1D7 (TBC1 Domain Family, Member 7 (TBC1D7))
- 别名
- TBC1D7 (TBC1D7 产品)
- 别名
- PIG51 antibody, TBC7 antibody, dJ257A7.3 antibody, 2610009C09Rik antibody, TBC1 domain family member 7 antibody, TBC1 domain family, member 7 antibody, TBC1D7 antibody, Tbc1d7 antibody
- 背景
- TBC1 domain family member 7 (TBC1D7, TBC7) belongs to a family of TBC (Tre-2/Bub2/Cdc16) containing proteins that function as GTPase-activating proteins (GAPs) . TBC1D7 was initially identified as a novel binding protein within the TSC1-TSC2 complex, where it was thought to associate with TSC1 . Additional research indicates that TBC1D7 is a third subunit of the TSC1-TSC2 complex that possesses Rheb-GAP activity and signals upstream of mTORC1. Knockdown of TBC1D7 limits the association between TSC1 and TSC2, resulting in reduced Rheb-GAP activity and increased mTORC1 signaling . Mutations in the corresponding TBC1D7 gene result in increased mTORC1 signaling, delayed autophagy, and are associated with intellectual disability (ID) and macrocrania.
- 分子量
- 36 kDa
- 基因ID
- 67046
- NCBI登录号
- NP_001239568
- UniProt
- Q9D0K0
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