TBC1D7 抗体
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北京 101111
Quick Overview for TBC1D7 抗体 (ABIN7075849)
抗原
See all TBC1D7 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 人, 大鼠
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纯化方法
- Affinity purification
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免疫原
- Recombinant protein corresponding to Mouse TBC1D7
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anti-TBC1 Domain Family, Member 7 (TBC1D7) (AA 1-293) antibody
TBC1D7 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-TBC1 Domain Family, Member 7 (TBC1D7) (AA 1-293) antibodyTBC1D7 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-TBC1 Domain Family, Member 7 (TBC1D7) (AA 154-203) antibodyTBC1D7 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB (H,M,R) 1: 500- 1: 1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS, pH 7.4, 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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- TBC1D7 (TBC1 Domain Family, Member 7 (TBC1D7))
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别名
- TBC1D7
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背景
- TBC1 domain family member 7 (TBC1D7, TBC7) belongs to a family of TBC (Tre-2/Bub2/Cdc16) containing proteins that function as GTPase-activating proteins (GAPs) . TBC1D7 was initially identified as a novel binding protein within the TSC1-TSC2 complex, where it was thought to associate with TSC1 . Additional research indicates that TBC1D7 is a third subunit of the TSC1-TSC2 complex that possesses Rheb-GAP activity and signals upstream of mTORC1. Knockdown of TBC1D7 limits the association between TSC1 and TSC2, resulting in reduced Rheb-GAP activity and increased mTORC1 signaling . Mutations in the corresponding TBC1D7 gene result in increased mTORC1 signaling, delayed autophagy, and are associated with intellectual disability (ID) and macrocrania.
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分子量
- 36 kDa
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基因ID
- 67046
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NCBI登录号
- NP_001239568
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UniProt
- Q9D0K0
抗原
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