TAL1 抗体
Our Local Distributor
北京 101111
Quick Overview for TAL1 抗体 (ABIN7075819)
抗原
See all TAL1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
交叉反应
- 大鼠
-
纯化方法
- Affinity purification
-
免疫原
- Recombinant protein corresponding to Mouse Tal1
-
-
-
-
应用备注
- IHC/IF (R) 1:800-1:1500/1:400-1:1000
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- PBS, pH 7.4, 0.02 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
-
- TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))
-
别名
- Tal1
-
背景
- Activation of TAL1 characterizes up to 60 % of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of TAL1 and the catalytic subunit of casein kinase alpha, a serine/ threonine protein kinase known to modulate the activity of other bHLH transcription factors.
-
基因ID
- 21349
-
NCBI登录号
- NP_001274317
-
UniProt
- P22091
-
途径
- Stem Cell Maintenance
抗原
-