PGC1 alpha + beta 抗体
This anti- antibody is a 兔 多克隆 antibody detecting in WB. Suitable for 人, 小鼠 和 大鼠.
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Quick Overview for PGC1 alpha + beta 抗体 (ABIN7075028)
抗原
PGC1 alpha + beta
适用
人, 小鼠, 大鼠
宿主
兔
克隆类型
多克隆
标记
非结合性
应用范围
Western Blotting (WB)
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交叉反应
- 小鼠, 大鼠
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纯化方法
- Affinity purification
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免疫原
- KLH conjugated Synthetic peptide corresponding to Human PGC1alpha+beta
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anti-PGC1 alpha + beta antibody
适用: 人 WB 宿主: 兔 Monoclonal unconjugated
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应用备注
- WB (H,M,R) 1: 500-1: 1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS, pH 7.4, 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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- PGC1 alpha + beta
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背景
- PGC-1αis a transcriptional coactivator that regulates the genes involved in energy metabolism. It is the master regulator of mitochondrial biogenesis. This protein interacts with the nuclear receptor PPAR-γ, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element-binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor causing slow-twitch rather than fast-twitch muscle fiber types. Endurance exercise has been shown to activate the PGC-1α gene in human skeletal muscle. Exercise-induced PGC-1αin skeletal muscle increases autophagy and unfolded protein response. PGC-1α protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.
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分子量
- 91 kDa
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基因ID
- 19017
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NCBI登录号
- NP_001317680
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UniProt
- Q9UBK2
抗原
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