Piwil/ Mili (AA 885-973) 抗体 (Cy7)
Quick Overview for Piwil/ Mili (AA 885-973) 抗体 (Cy7) (ABIN704552)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 885-973
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Dog,Cow,Pig,Rabbit,Guinea Pig
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human Piwil/Mili
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亚型
- IgG
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应用备注
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FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- Piwil/ Mili
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别名
- Piwil/Mili
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背景
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Synonyms: HILI, Hiwi like, MILI, Miwi like, Piwi like 2, Piwi-like 2, Piwil 2, Piwil-2, Piwil2, Cancer/testis antigen 80, CT80, PIWL2_HUMAN, Piwil 1, Piwil 3, Piwil1, Piwil3, Piwi-like protein 1, PL2L60
Background: HILI is a 973 amino acid protein encoded by the human gene PIWIL2. HILI belongs to the argonaute family and contains one PAZ domain and one PIWI domain. HILI is a cytoplasmic protein that is expressed in adult testis and in most tumors. It regulates spermatogenesis and primordial germ cell production and has an essential role in meiotic differentiation of spermatocytes and in self-renewal of spermatogonial stem cells. Expression of HILI can modulate expression of genes involved in stem cell proliferation (such as PDGFR-b), in energy metabolism (such as Glut1), in cell-cell interaction (such as Integrin a6, GJA7, THY-1 and CD9), and in germ cell differentiation (such as STRA8). It may also play a role as a regulatory factor of Stat3/Bcl-xS/L/CCND1 pathway. Repression of HILI can inhibit tumor cell growth. HILI acts as an oncogene by inhibition of apoptosis and promotion of proliferation in tumors.
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分子量
- 95kDa
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基因ID
- 55124
抗原
-
