LAT 抗体
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北京 101111
Quick Overview for LAT 抗体 (ABIN7074502)
抗原
See all LAT 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 人, 大鼠
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纯化方法
- Affinity purification
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免疫原
- Recombinant protein corresponding to Mouse LAT
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anti-Linker For Activation of T Cells (LAT) (Cytoplasmic Domain) antibody
LAT 适用: 人 WB, IP, ICFC 宿主: 小鼠 Monoclonal LAT-01 unconjugated
anti-Linker For Activation of T Cells (LAT) (pTyr191) antibodyLAT 适用: 人 WB, ELISA, IHC, IP, IF 宿主: 兔 Monoclonal 2E4 unconjugated Recombinant Antibody
anti-Linker For Activation of T Cells (LAT) antibodyKD Validated LAT 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB4940 unconjugated Recombinant Antibody
anti-Linker For Activation of T Cells (LAT) (AA 1-233) antibodyLAT 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3B11-1D5 unconjugated
anti-Linker For Activation of T Cells (LAT) (AA 30-237) antibodyLAT 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Linker For Activation of T Cells (LAT) (pTyr161) antibodyLAT 适用: 人 ELISA, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Linker For Activation of T Cells (LAT) (Cytoplasmic Domain) antibodyLAT 适用: 人 WB, IHC, IP, IHC (p) 宿主: 小鼠 Monoclonal LAT1111 unconjugated
anti-Linker For Activation of T Cells (LAT) (AA 25-221) antibodyLAT 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Linker For Activation of T Cells (LAT) (AA 33-227) antibodyLAT 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Linker For Activation of T Cells (LAT) (AA 28-233) antibodyLAT 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB (M,R) 1:500-1:1000, IHC/IF (H,M,R) 1:1000-1:4000/1:500-1:3000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS, pH 7.4, 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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- LAT (Linker For Activation of T Cells (LAT))
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别名
- LAT
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背景
- Linker for activation of T-cells family member 1 (LAT) is a single-pass type III membrane protein which is required for TCR (T-cell antigen receptor) and pre-TCR-mediated signaling, both in mature T-cells and during their development This protein is involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Functionally T cell receptor (TCR) activation results in tyrosine phosphorylation of LAT, leading to the direct interaction with several proteins, including PLC-gamma 1, Grb2 and Gads. These direct ligands then mediate the indirect interaction of LAT with proteins such as SLP-76, Vav1 and Itk. PLC-gamma 1, Vav1 and Itk contain pleckstrin homology (PH) domains that interact with the enzymatic product of phosphoinositide-3-kinase (PI3k).
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分子量
- 38 kDa
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基因ID
- 16797
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NCBI登录号
- NP_034819
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UniProt
- O54957
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途径
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway
抗原
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