H2-AB1 抗体
The 兔 多克隆 anti-H2-AB1 antibody is suitable to detect H2-AB1 in samples from 小鼠 和 大鼠. It has been validated for IF 和 IHC.
产品编号 ABIN7074228
发货至:
中国
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Quick Overview for H2-AB1 抗体 (ABIN7074228)
抗原
H2-AB1
(Histocompatibility 2, Class II Antigen A, beta 1 (H2-AB1))
适用
小鼠, 大鼠
宿主
兔
克隆类型
多克隆
标记
This H2-AB1 antibody is un-conjugated
应用范围
Immunofluorescence (IF), Immunohistochemistry (IHC)
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交叉反应
- 大鼠
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纯化方法
- Affinity purification
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免疫原
- Recombinant protein corresponding to Mouse H2ab1
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anti-Histocompatibility 2, Class II Antigen A, beta 1 (H2-AB1) antibody
H2-AB1 适用: 小鼠 IF, IHC, WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- IHC/IF (M,R) 1:4000-1:8800
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS, pH 7.4, 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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- H2-AB1 (Histocompatibility 2, Class II Antigen A, beta 1 (H2-AB1))
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别名
- H2ab1
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背景
- Atypical histone H2A which replaces conventional H2A during late spermatogenesis and is involved in the replacement of histones to protamine in male germ cells . Core component of nucleosome: nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template . Nucleosomes containing H2AB1 only wrap 130 bp of DNA, compared to 147 bp for classical nucleosomes . In condensing spermatids, the heterodimer between H2AB1 and H2BC1/TH2B is loaded onto the nucleosomes and promotes loading of transition proteins (TNP1 and TNP2) onto the nucleosomes . Inclusion of the H2AB1-H2BC1/TH2B dimer into chromatin opens the nucleosomes, releasing the nucleosomal DNA ends and allowing the invasion of nucleosomes by transition proteins (TNP1 and TNP2) .
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基因ID
- 68231
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NCBI登录号
- NP_080903
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UniProt
- Q9CQ70
抗原
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