GDF5 抗体
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北京 101111
Quick Overview for GDF5 抗体 (ABIN7074131)
抗原
See all GDF5 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 人, 大鼠
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纯化方法
- Affinity purification
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免疫原
- KLH conjugated Synthetic peptide corresponding to Mouse GDF 5
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应用备注
- WB (H,M) 1:500-1:1000, IHC/IF (H,R) 1:200-1:400
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS, pH 7.4, 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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- GDF5 (Growth Differentiation Factor 5 (GDF5))
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别名
- GDF 5
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背景
- Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction . Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG . Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 .
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分子量
- 55 kDa
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基因ID
- 14563
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NCBI登录号
- NP_032135
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UniProt
- P43027
抗原
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