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CSN2 抗体

This 兔 多克隆 antibody specifically detects CSN2 in IHC 和 IF. It exhibits reactivity toward 小鼠 和 大鼠.
产品编号 ABIN7073324
发货至: 中国
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中国
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
4A Biotech Co.,Ltd.
Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for CSN2 抗体 (ABIN7073324)

抗原

See all CSN2 抗体
CSN2 (Casein beta (CSN2))

适用

  • 56
  • 49
  • 34
  • 3
  • 1
小鼠, 大鼠

宿主

  • 82
  • 4

克隆类型

  • 70
  • 16
多克隆

标记

  • 25
  • 7
  • 6
  • 5
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This CSN2 antibody is un-conjugated

应用范围

  • 77
  • 27
  • 27
  • 27
  • 15
  • 11
  • 10
  • 8
  • 5
  • 2
  • 1
  • 1
Immunohistochemistry (IHC), Immunofluorescence (IF)
  • 交叉反应

    大鼠

    纯化方法

    Affinity purification

    免疫原

    Recombinant protein corresponding to Mouse CSN2
  • 应用备注

    IHC/IF (M,R) 1:700-1:1400

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS, pH 7.4, 0.02 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C
  • 抗原

    CSN2 (Casein beta (CSN2))

    别名

    CSN2

    背景

    COPS2 is an essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

    基因ID

    12848

    NCBI登录号

    NP_001272441

    UniProt

    P61202
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