CSN2 抗体
Quick Overview for CSN2 抗体 (ABIN7073324)
抗原
See all CSN2 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 大鼠
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纯化方法
- Affinity purification
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免疫原
- Recombinant protein corresponding to Mouse CSN2
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anti-Casein beta (CSN2) (AA 41-198) antibody
CSN2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Casein beta (CSN2) (AA 16-100) antibodyCSN2 适用: 人, Cow, 山羊 WB, ELISA, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Casein beta (CSN2) (AA 151-222) antibodyCSN2 适用: 人, Cow, 山羊, 绵羊 WB, ELISA, IF (cc), IF (p), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Casein beta (CSN2) (AA 25-54), (N-Term) antibodyCSN2 适用: 人 WB 宿主: 兔 Polyclonal RB31320 unconjugated
anti-Casein beta (CSN2) (AA 16-226) antibodyCSN2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Casein beta (CSN2) (AA 16-224) antibodyCSN2 适用: Cow WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Casein beta (CSN2) (AA 127-226) antibodyCSN2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- IHC/IF (M,R) 1:700-1:1400
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS, pH 7.4, 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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- CSN2 (Casein beta (CSN2))
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别名
- CSN2
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背景
- COPS2 is an essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
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基因ID
- 12848
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NCBI登录号
- NP_001272441
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UniProt
- P61202
抗原
-
