WTX 抗体
Quick Overview for WTX 抗体 (ABIN7073078)
抗原
See all WTX (AMER1) 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 人, 大鼠
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纯化方法
- Affinity purification
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免疫原
- Recombinant protein corresponding to Mouse FAM123B
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anti-APC Membrane Recruitment Protein 1 (AMER1) antibody
AMER1 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-APC Membrane Recruitment Protein 1 (AMER1) (AA 681-708) antibodyAMER1 适用: 人, 小鼠 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB18795 unconjugated
anti-APC Membrane Recruitment Protein 1 (AMER1) antibodyAMER1 适用: 人, 小鼠 IHC, WB, FACS 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB (H,M,R) 1: 500-1: 1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS, pH 7.4, 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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- WTX (AMER1) (APC Membrane Recruitment Protein 1 (AMER1))
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别名
- FAM123B
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背景
- Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development.
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分子量
- 125 kDa
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基因ID
- 72345
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NCBI登录号
- NP_780388
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UniProt
- Q7TS75
抗原
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