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Recombinant CCR7 抗体

This anti-CCR7 antibody is a 兔 Chimeric antibody detecting CCR7 in FACS, IP 和 Func. Suitable for 小鼠.
产品编号 ABIN7072672
发货至: 中国

Quick Overview for Recombinant CCR7 抗体 (ABIN7072672)

抗原

See all CCR7 抗体
CCR7 (Chemokine (C-C Motif) Receptor 7 (CCR7))

抗体类型

Recombinant Antibody

适用

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小鼠

宿主

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克隆类型

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Chimeric

标记

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This CCR7 antibody is un-conjugated

应用范围

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Flow Cytometry (FACS), Immunoprecipitation (IP), Functional Studies (Func)

克隆位点

4B12
  • 原理

    Anti-CCR7 [4B12], Rabbit IgG, kappa

    特异性

    This antibody is specific to the mouse CCR7 protein, which was confirmed by immunoprecipitation (Ritter et al, 2004).

    产品特性

    Original Species of Ab: Rat

    Original Format of Ab: IgG2a

    纯化方法

    Protein A affinity purified

    免疫原

    This antibody was raised by immunizing rats with mouse CCR7 antigen.

    亚型

    IgG kappa
  • 应用备注

    This antibody was used for flow cytometry and the staining quality can be improved by incubation at 37 °C (Britschgi et al, 2008). This antibody is widely used to monitor the activation of dendritic cells in mice (Ohl et al, 2004, Ritter et al, 2004, Zhao et al, 2019). It was also utilized in immunoprecipitation of the CCR7 receptor protein (Ritter et al, 2004). The antibody does not interfere with ligands binding to the CCR7 receptor, which was confirmed by a transmigration assay (Ritter et al, 2004). It does not interfere with T-cell migration (Ritter et al, 2004). The antibody also is not agonistic as it does not activate the receptor (Ritter et al, 2004).

    说明

    This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG2a format, for improved compatibility with existing reagents, assays and techniques.

    限制

    仅限研究用
  • 浓度

    1 mg/mL

    缓冲液

    PBS with 0.02 % Proclin 300.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • 抗原

    CCR7 (Chemokine (C-C Motif) Receptor 7 (CCR7))

    别名

    CCR7

    背景

    EBI1, EBV-induced G-protein coupled receptor 1, Epstein-Barr virus-induced G-protein coupled receptor 1, MIP-3 beta receptor, CD197, C-C CKR-7, CC-CKR-7, C-C chemokine receptor type 7

    UniProt

    P47774

    途径

    Regulation of Actin Filament Polymerization, Positive Regulation of Immune Effector Process
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