Recombinant VCAM1 抗体
Quick Overview for Recombinant VCAM1 抗体 (ABIN7072646)
抗原
See all VCAM1 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Anti-CD106 [B-K9 (C106-K9)], Rabbit IgG, kappa
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特异性
- B-K9 antibody recognizes CD106 (VCAM1). CD106 is a member of the Ig superfamily. It is a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis.
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产品特性
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Original Species of Ab: Mouse
Original Format of Ab: IgG1
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纯化方法
- Protein A affinity purified
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免疫原
- This antibody was raised by immunizing Balb/c mice against activated human umbilical vein endothelial cells (HUVEC).
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亚型
- IgG kappa
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应用备注
- B-K9 antibody inhibits the binding of leukocytes to VCAM-1 on stimulated endothelial cells, and thus it blocks the ability of white blood cells to attach themselves to the activated epithelium during, for instance, inflammation. Consequently, this antibody might be used in research where leukocytes adhesion-blocking is required (Uotila et al., 2014, Wagner et al. 2011).
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说明
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This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- VCAM1 (Vascular Cell Adhesion Molecule 1 (VCAM1))
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别名
- CD106
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背景
- VCAM1, Vascular cell adhesion protein 1, V-CAM 1, INCAM-100
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UniProt
- P19320
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途径
- Carbohydrate Homeostasis
抗原
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