Recombinant gamma-Aminobutyric Acid Receptor Subunit beta (RDL) 抗体
The 兔 Chimeric anti-gamma-Aminobutyric Acid Receptor Subunit beta antibody is suitable to detect gamma-Aminobutyric Acid Receptor Subunit beta in samples from 人. It has been validated for Crys 和 SEC-HPLC.
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产品编号 ABIN7072589
发货至:
中国
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Quick Overview for Recombinant gamma-Aminobutyric Acid Receptor Subunit beta (RDL) 抗体 (ABIN7072589)
抗原
gamma-Aminobutyric Acid Receptor Subunit beta (RDL)
抗体类型
Recombinant Antibody
适用
人
宿主
兔
克隆类型
Chimeric
标记
非结合性
应用范围
Crystallization (Crys), Size-exclusion chromatography-High Pressure Liquid Chromatography (SEC-HPLC)
克隆位点
1F4
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原理
- Anti-GABAR [1F4], Rabbit IgG, kappa
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特异性
- This antibody recognises α1β2γ2 GABA-A receptor which is found in up to 50 % of the synapses in the brain. It's ligand, GABA is a major inhibitory transmitter in the nervous system, binds to this receptor and opens a channel permeable to chloride. Disfunctions of GABAR are found in anxiety, neurodevelopmental disorderds and epilepsy.
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产品特性
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Original Species of Ab: Mouse
Original Format of Ab: IgG2b
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纯化方法
- Protein A affinity purified
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免疫原
- This antibody was raised against alpha1beta2gamma2 GABA-A receptor.
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亚型
- IgG kappa
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应用备注
- FSEC: High affinity and specificity of the 1F4 antibody to α1β2γ2 GABA-A receptor was demonstrated using fluorescence-detection size exclusion chromatography with GFP-tagged receptor (shift in elution volume) (Zhu et al., 2018). Crystallography: Furthermore, this antibody was utilised in production and purification of the α1β2γ2 GABA-A receptor (Zhu et al., 2018). Finally, Fab fragments derived from the antibody were used to facilitate crystallisation and improve stabilisation of the α1β2γ2 GABA-A receptor (Zhu et al., 2018).
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说明
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This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2b format, for improved compatibility with existing reagents, assays and techniques.
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- gamma-Aminobutyric Acid Receptor Subunit beta (RDL)
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别名
- GABAR
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背景
- Gamma-aminobutyric acid receptor A, Gamma-aminobutyric acid receptor, Gamma-aminobutyric acid receptor subunit alpha-1, Gamma-aminobutyric acid receptor subunit beta-2, Gamma-aminobutyric acid receptor subunit gamma-2, GABA(A), GABA-A receptor, α1β2γ2 GABA-A receptor
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UniProt
- P14867, P47870, P18507
抗原
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