Recombinant MS4A4A 抗体
Quick Overview for Recombinant MS4A4A 抗体 (ABIN7072576)
抗原
See all MS4A4A 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Anti-MS4A4A [5C12], Rabbit IgG, lambda
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特异性
- This antibody is specific for human extracellular MS4A4A. 5C12 mAb only partially cross-blocked either 4H2 (Ab01373) and 3F2 (Ab01375) and therefore probably detects a unique or overlapping epitope (Sanyal et al., 2017, pmid: 28303902). MS4A (membrane-spanning 4-domain family, subfamily A) is a large family of proteins that includes at least 26 members in mouse and humans. Flanked by amino- and carboxyl- cytoplasmic regions, MS4A family members contain four highly conserved transmembrane domains connected by short extracellular and cytoplasmic loops. MS4A4A is likely to be a component of oligomeric cell surface complexes involved in signal transduction in diverse cell lineages.
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产品特性
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Original Species of Ab: Mouse
Original Format of Ab: IgG1
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纯化方法
- Protein A affinity purified
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免疫原
- This antibody was generated by immunizing C57BL/6 mice against mouse cell line 300-19 expressing transfected human membrane-spanning 4-domains subfamily A member 4A (MS4A4A)-GFP.
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亚型
- IgG lambda
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anti-Membrane-Spanning 4-Domains, Subfamily A, Member 4 (MS4A4A) (AA 1-64) antibody
MS4A4A 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Membrane-Spanning 4-Domains, Subfamily A, Member 4 (MS4A4A) (AA 1-220) antibodyMS4A4A 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Membrane-Spanning 4-Domains, Subfamily A, Member 4 (MS4A4A) (AA 1-239) antibodyMS4A4A 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Membrane-Spanning 4-Domains, Subfamily A, Member 4 (MS4A4A) (N-Term) antibodyMS4A4A 适用: 人, 犬, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Membrane-Spanning 4-Domains, Subfamily A, Member 4 (MS4A4A) (AA 37-64), (N-Term) antibodyMS4A4A 适用: 人 FACS, WB 宿主: 兔 Polyclonal RB28710 unconjugated
anti-Membrane-Spanning 4-Domains, Subfamily A, Member 4 (MS4A4A) (AA 40-68), (N-Term) antibodyMS4A4A 适用: 人 FACS, WB, EIA 宿主: 兔 Polyclonal unconjugated
anti-Membrane-Spanning 4-Domains, Subfamily A, Member 4 (MS4A4A) antibodyMS4A4A 适用: 人 FACS, WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- 5C12 is recommended for the detection and analysis of expression of MS4A4A. Importantly, MS4A4A has been shown to be a marker for M2 macrophages and plasma cells and to be overexpressed in multiple myelomas, suggesting a potential role in targeting alternatively activated macrophages such as tumor-associated macrophages, and in the treatment of multiple myeloma and mantle cell lymphoma (Sanyal et al., 2017, pmid: 28303902). The antibody 5C12 can be successfully used for the detection of MS4A4A-expressing cells via flow cytometry (Sanyal et al., 2017, pmid: 28303902). Finally, specificity of this antibody was additionally confirmed via immunoprecipitation of lysates of BJAB MS4A4A-HA cells (Sanyal et al., 2017, pmid: 28303902).
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说明
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This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- MS4A4A (Membrane-Spanning 4-Domains, Subfamily A, Member 4 (MS4A4A))
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别名
- MS4A4A
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背景
- Four-span transmembrane protein 1, human membrane-spanning 4-domains subfamily A member 4A, CD20 antigen-like 1, (MS4A4A)-GFP, MS4A4, 4SPAN1, MS4A
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UniProt
- Q96JQ5
抗原
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