Recombinant CMKLR1 抗体 (AA 8-32)
Quick Overview for Recombinant CMKLR1 抗体 (AA 8-32) (ABIN7072487)
抗原
See all CMKLR1 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 8-32
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原理
- Anti-CMKLR1 [BZ194], Rabbit IgG, kappa
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特异性
- This antibody is specific for murine serpentine receptor mCMKLR1 (aka ChemR23, DEZ). mCMKLR1 is a novel protein possessing high homology with members of the chemoattractant receptor family, and binds the chemoattractant chemerin. Selective mCMKLR1 expression has been demonstrated by mouse macrophages ex vivo, and by dendritic cell precursors cultured in vitro.
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产品特性
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Original Species of Ab: Rat
Original Format of Ab: IgG2a
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纯化方法
- Protein A affinity purified
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免疫原
- This antibody was raised by immunising Wistar Furth rats with the mCMKLR1 peptide/KLH conjugate. The immunizing amino-terminal mCMKLR1 peptide with the sequence NH2-DSGIYDDEYSDGFGYFVDLEEASPWC-COOH, corresponding to residues residues 8-32 of mCMKLR1, with a nonnative carboxyl-terminal cysteine to facilitate conjugation to keyhole limpet hemocyanin (KLH).
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亚型
- IgG kappa
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anti-Chemokine-Like Receptor 1 (CMKLR1) (AA 321-373) antibody
CMKLR1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Chemokine-Like Receptor 1 (CMKLR1) (AA 151-250) antibodyCMKLR1 适用: 人, 小鼠, 大鼠, Pig WB, ELISA, IF (cc), IF (p), FACS, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine-Like Receptor 1 (CMKLR1) (AA 305-333), (C-Term) antibodyCMKLR1 适用: 人 WB 宿主: 兔 Polyclonal RB42353 unconjugated
anti-Chemokine-Like Receptor 1 (CMKLR1) (N-Term) antibodyCMKLR1 适用: 人, 犬, 猴, 兔 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine-Like Receptor 1 (CMKLR1) (AA 171-280) antibodyCMKLR1 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine-Like Receptor 1 (CMKLR1) (C-Term) antibodyCMKLR1 适用: 人, Pig, Cow, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Chemokine-Like Receptor 1 (CMKLR1) (AA 250-350) antibodyCMKLR1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Chemokine-Like Receptor 1 (CMKLR1) (AA 250-350) antibodyCMKLR1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Chemokine-Like Receptor 1 (CMKLR1) (C-Term) antibodyCMKLR1 适用: 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Chemokine-Like Receptor 1 (CMKLR1) (Center) antibodyCMKLR1 适用: 人, 小鼠, 大鼠, Pig WB, IHC, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
- The anti-mCMKLR1 BZ194 generates a robust staining signal when used in flow cytometry applications with mCMKLR1+ cells (Zabel et al., 2006). This antibody, together with other mAbs directed against chemokine receptors, could be used to determine the leukocyte expression profile of receptors during homeostasis or inflammation, to elucidate the role of various receptors in coordinating the immune response and in leukocyte development, and to identify other proteins interacting with the chemokine receptor. In particular, this antibody has been used to evaluate the functional responses of mCMKLR1-expressing cells to chemerin (Zabel et al., 2006), to demonstrate the esssential role of natural killer cells in resolution of antigen-induced inflammation in mice (Anuforo et al., 2018), to indicate a potential role for chemerin and CMKLR1 in the regulation of inflammatory responses in the tumor microenvironment (Rama et al, 2011), to visualise immediate immune responses to pioneer metastatic cells in the lung (Headley et al., 2016), and to investigate the regulatory role of chemerin in lung tumorigenesis and cancer-associated inflammation (Unver et al, 2018).
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说明
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This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG2a format, for improved compatibility with existing reagents, assays and techniques.
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- CMKLR1 (Chemokine-Like Receptor 1 (CMKLR1))
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别名
- CMKLR1
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背景
- Chemerin receptor, CHEMERINR, chemokine receptor-like 1, Chemokine-like receptor 1, ChemR23, CMKLR1, DEZ, G-protein coupled receptor ChemR23, G-protein coupled receptor DEZ, orphan G-protein coupled receptor, Dez, Resolvin E1 receptor, RVER1, Gpcr27, MGC126105, MGC126106
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UniProt
- P97468
抗原
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