Recombinant GPIIb/IIIa 抗体
This anti-GPIIb/IIIa antibody is a 兔 Chimeric antibody detecting GPIIb/IIIa in ELISA, IF 和 WB. Suitable for 人.
Quick Overview for Recombinant GPIIb/IIIa 抗体 (ABIN7072340)
抗原
See all GPIIb/IIIa 抗体
GPIIb/IIIa
(Platelet Glycoprotein IIb-IIIa Complex (GPIIb/IIIa))
抗体类型
Recombinant Antibody
适用
人
宿主
兔
克隆类型
Chimeric
标记
This GPIIb/IIIa antibody is un-conjugated
应用范围
ELISA, Immunofluorescence (IF), Western Blotting (WB)
克隆位点
10E5
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原理
- Anti-GPIIb/IIIa [10E5], Rabbit IgG, kappa
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特异性
- The antibody binds to GPIIb/IIIa with an affinity (Kd) of 16.2±6 nM. The antibody completely inhibits platelet aggregation at 7.8 μg/mL.
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产品特性
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Original Species of Ab: Mouse
Original Format of Ab: IgG2a
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纯化方法
- Protein A affinity purified
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免疫原
- Human blood platelets.
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亚型
- IgG kappa
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应用备注
- The antibody binds specifically to human GPIIb/IIIa, and integrin complex of membrane glycoproteins expressed on the surface of platelets. The GPIIb/IIIa complex acts as a receptor for fibrinogen and Von Willebran factor, hemostatic glycoproteins that mediate platelet aggregation and blood coagulation. The monoclonal antibody 10E5 inhibits the binding of fibrinogen to its platelet receptor, preventing the platelet aggregation, to be used during coronary artery surgeries such as angioplasty. The antibody is also useful in the study of the disease Glanzmann's thrombasthenia, caused by defects in GPIIb/IIIa, and of immune thrombocytopenic purpura, where autoantibodies are produced against GPIIb/IIIa.
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说明
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This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- GPIIb/IIIa (Platelet Glycoprotein IIb-IIIa Complex (GPIIb/IIIa))
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别名
- GPIIb/IIIa
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背景
- Integrin alpha-IIb/beta-3, Glycoprotein IIb/IIIa, αIIbβ3
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UniProt
- P08514
抗原
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