Recombinant IgE 抗体
Quick Overview for Recombinant IgE 抗体 (ABIN7072336)
抗原
See all IgE 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Anti-IgE [TES-C21], Mouse IgG1, kappa
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产品特性
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Original Species of Ab: Mouse
Original Format of Ab: IgG
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纯化方法
- Protein A affinity purified
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免疫原
- Polyclonal human IgE.
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亚型
- IgG1 kappa
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anti-IgE antibody
适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 4G7-325 unconjugated
anti-IgE antibody (PE)适用: 人 FACS 宿主: 小鼠 Monoclonal 4H10 PE
anti-IgE antibody (APC)适用: 人 FACS 宿主: 小鼠 Monoclonal 4H10 APC
anti-IgE antibody (FITC)适用: 人 FACS 宿主: 小鼠 Monoclonal BE5 FITC
anti-IgE antibody (Biotin)适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal BE5 Biotin
anti-IgE antibody (PE)适用: 人 FACS 宿主: 小鼠 Monoclonal BE5 PE
anti-IgE (AA 1-421) antibody适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
- The antibody binds specifically to IgE, an immunoglobulin isotype secreted by upon stimulation of B cells by interleukins Il-4 and IL-13. IgE provides immunity to parasites such as helminths and Plasmodium falciparum. The immunoglobulin also plays a central role in the development of Type I hypersensitivity reactions and allergic diseases such as asthma, sinusitis and food allergies. These allergic responses are triggered by the binding of IgE to the high affinity receptor FcεRI, expressed on the surface of basophils and mast cells. Binding of IgE causes cross-linking of the receptor, inducing degranulation and release of inflammatory mediators, particularly of histamine. The monoclonal antibody TES-C21 binds to secreted IgE and to IgE expressed on the surface of IgE-producing B cells, thereby inhibiting IgE binding to FcεRI and the release of histamine from mast cells. The monoclonal antibody can have diagnostic applications, such as for identifying and quantifying IgE-expressing B cells and IgE levels in serum samples, and therapeutic applications in the treatment of allergies. Furthermore, the antibody can conjugated to cytotoxic drugs and deliver them specifically to IgE-producing B cells.
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说明
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This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG format, for improved compatibility with existing reagents, assays and techniques.
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- IgE
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背景
- Immunoglobulin E
抗原
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