Recombinant LeY 抗体
The 小鼠 单克隆 anti-LeY antibody (Clone BR96) (ABIN7072332) specifically detects LeY in ELISA 和 IHC.
The antibody is reactive with 人 samples.
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产品编号 ABIN7072332
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
Quick Overview for Recombinant LeY 抗体 (ABIN7072332)
抗原
LeY
抗体类型
Recombinant Antibody
适用
人
宿主
小鼠
克隆类型
单克隆
标记
非结合性
应用范围
ELISA, Immunohistochemistry (IHC)
克隆位点
BR96
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原理
- Anti-LeY [BR96], Mouse IgG1, kappa
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特异性
- The antibody binds Le(Y) with a Ka of 0.1 μM.
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产品特性
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Original Species of Ab: Mouse
Original Format of Ab: IgG3
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纯化方法
- Protein A affinity purified
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免疫原
- H3396 cultured line established from a metastasis of a human breast adenocarcinoma.
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亚型
- IgG1 kappa
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应用备注
- The antibody binds specifically to LeY tetrasaccharide, a carbohydrate antigen expressed at the cell surface of selective carcinomas, including those of the colon, breast, ovary and lung. Studies have shown that the monoclonal antibody has toxic effects to antigen-positive tumour cells, performing ADCC at concentrations down to 0.1 μg/mL. The antibody B396 was also shown to perform complement-dependent cytotoxicity at concentrations of 0.1-5.0 μg/mL in certain carcinoma cell lines. The monoclonal antibody also has the ability to be internalised by antigen-positive tumour cells, and can thereby be used to deliver anti-cancer drugs to the specific tumour cells.
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说明
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This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG3 format, for improved compatibility with existing reagents, assays and techniques.
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- LeY
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背景
- Lewis Y
抗原
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