TMEM38B 抗体 (Intracellular)
Quick Overview for TMEM38B 抗体 (Intracellular) (ABIN7043862)
抗原
See all TMEM38B 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 116-126, Intracellular
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原理
- A Rabbit Polyclonal Antibody to TRIC-B Channel
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特异性
- Intracellular, cytoplasmic loop
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse,human - identical
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产品特性
- Anti-TRIC-B (TMEM38B) Antibody (ABIN7043862 and ABIN7045314) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot, immunohistochemistry, and immunocytochemistry applications. It has been designed to recognize TRIC-B from rat, mouse, and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)GMKEVTRTWKIVG, corresponding to amino acid residues 116-126 of rat TRIC-B
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亚型
- IgG
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anti-Transmembrane Protein 38B (TMEM38B) (AA 249-291) antibody
TMEM38B 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Protein 38B (TMEM38B) (C-Term) antibodyTMEM38B 适用: 人, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Protein 38B (TMEM38B) (C-Term) antibodyTMEM38B 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:200
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说明
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Negative Control: (ABIN7237524)
Blocking Peptide: (ABIN7237524)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- TMEM38B (Transmembrane Protein 38B (TMEM38B))
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别名
- TMEM38B
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背景
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Trimeric intracellular cation channel type B, Transmembrane protein 38B,Intracellular Ca2+ levels are important in proper cellular functions and have prominent roles in various cell signaling pathways and are crucial for muscle contractions. Indeed, an important step leading to muscle contraction is the massive release of Ca2+ ions from the endoplasmic/sarcoplasmic reticulum (ER/SR) to the cytosol. A battery of results suggest that specific K+ channels are important to counteract the Ca2+ outflow in order to neutralize the negative potential created by the movement of Ca2+ ions. It is believed that TRIC channels are responsible for neutralizing this negative potential1,2.Trimeric intracellular cation-specific (TRIC) channels are critical for proper management of intracellular stores. TRIC-A and TRIC-B both belong to this family and are both permeable to monovalent ions with a preference for K+ 3. Both channels are localized to the ER/SR membrane. Each TRIC subunit contains three transmembrane domains, a cytoplasmic C-terminus and a luminal N-terminus. Functional entities are formed by homotrimerizarion4. The activity of TRIC-A is regulated by voltage whereas that of TRIC-B can be regulated by different mechanisms3.Knockout studies of these channels have shown that TRIC-A knockout mice are viable while those of TRIC-B die at the neonatal stage5.TRIC-A is mostly expressed in excitable tissues like the brain and muscle while TRIC-B is ubiquitously expressed.
Alternative names: TRIC-B (TMEM38B), Trimeric intracellular cation channel type B, Transmembrane protein 38B -
基因ID
- 362521
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NCBI登录号
- NM_018112
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UniProt
- Q68FV1
抗原
-
