TMEM38A 抗体 (Intracellular)
Quick Overview for TMEM38A 抗体 (Intracellular) (ABIN7043861)
抗原
See all TMEM38A 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 259-274, Intracellular
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原理
- A Rabbit Polyclonal Antibody to TRIC-A Channel
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特异性
- Intracellular, C-terminus
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交叉反应
- 小鼠, 大鼠
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预测反应
- Mouse - identical, human - will not recognize human TRIC-A
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产品特性
- Anti-TRIC-A (TMEM38A) Antibody (ABIN7043861 and ABIN7045315) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot, immunohistochemistry, and immunocytochemistry applications. It has been designed to recognize TRIC-A from rat and mouse samples. The antibody is not suited to recognize TRIC-A from human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)DNHGAPHGMGLGTQHS, corresponding to amino acid residues 259-274 of rat TRIC-A
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亚型
- IgG
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anti-Transmembrane Protein 38A (TMEM38A) (C-Term) antibody
TMEM38A 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Protein 38A (TMEM38A) (AA 1-299) antibodyTMEM38A 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Transmembrane Protein 38A (TMEM38A) (AA 74-123) antibodyTMEM38A 适用: 人, 大鼠, 马, Pig, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Protein 38A (TMEM38A) (N-Term) antibodyTMEM38A 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Protein 38A (TMEM38A) (N-Term) antibodyTMEM38A 适用: 人, 大鼠, 小鼠, 马, Pig, 兔, Cow, 犬, 豚鼠, Saccharomyces cerevisiae WB 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Protein 38A (TMEM38A) (C-Term) antibodyTMEM38A 适用: 人, 大鼠, 小鼠 WB, EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:200
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说明
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Cited Application: IHC
Negative Control: (ABIN7237521)
Blocking Peptide: (ABIN7237521)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- TMEM38A (Transmembrane Protein 38A (TMEM38A))
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别名
- TMEM38A
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背景
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Trimeric intracellular cation channel type A, 27 kDa sarcoplasmic reticulum protein, Transmembrane protein 38A,Intracellular Ca2+ levels are important in proper cellular functions and have prominent roles in various cell signaling pathways and are crucial for muscle contractions. Indeed, an important step leading to muscle contraction is the massive release of Ca2+ ions from the endoplasmic/sarcoplasmic reticulum (ER/SR) to the cytosol. A battery of results suggest that specific K+ channels are important to counteract the Ca2+ outflow in order to neutralize the negative potential created by the movement of Ca2+ ions. It is believed that TRIC channels are responsible for neutralizing this negative potential1,2.Trimeric intracellular cation-specific (TRIC) channels are critical for proper management of intracellular stores. TRIC-A and TRIC-B both belong to this family and are both permeable to monovalent ions with a preference for K+ 3. Both channels are localized to the ER/SR membrane. Each TRIC subunit contains three transmembrane domains, a cytoplasmic C-terminus and a luminal N-terminus. Functional entities are formed by homotrimerizarion4. The activity of TRIC-A is regulated by voltage whereas that of TRIC-B can be regulated by different mechanisms3.Knockout studies of these channels have shown that TRIC-A knockout mice are viable while those of TRIC-B die at the neonatal stage5.TRIC-A is mostly expressed in excitable tissues like the brain and muscle while TRIC-B is ubiquitously expressed.
Alternative names: TRIC-A (TMEM38A), Trimeric intracellular cation channel type A, 27 kDa sarcoplasmic reticulum protein, Transmembrane protein 38A -
基因ID
- 306327
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NCBI登录号
- NM_024074
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UniProt
- A6ZIQ8
抗原
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