TRPV6 抗体 (Extracellular)
Our Local Distributor
北京 101111
Quick Overview for TRPV6 抗体 (Extracellular) (ABIN7043856)
抗原
See all TRPV6 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 395-405, Extracellular
-
原理
- A Rabbit Polyclonal Antibody to Human TRPV6 Channel
-
特异性
- 1st extracellular loop
-
交叉反应 （详细）
- Not recommended for use in mouse and rat samples. Slight possibility, if any, for some cross reactivity with human TRPV5.
-
预测反应
- TRPV6 from human samples The antibody is unlikely to recognize the channel from rat,mouse samples In addition,there is a slight possibility,if any,for some cross-reactivity with human TRPV5
-
产品特性
- Anti-Human TRPV6 (extracellular) Antibody is directed against an epitope of the human TRPV6 channel. Anti-Human TRPV6 (extracellular) Antibody (ABIN7043856, ABIN7043984 and ABIN7043985) can be used in western blot and live cell imaging applications. It has been designed to recognize TRPV6 from human samples. The antibody is unlikely to recognize the channel from rat and mouse samples. In addition, there is a slight possibility, if any, for some cross-reactivity with human TRPV5.
-
纯化方法
- Affinity purified on immobilized antigen.
-
免疫原
-
Immunogen: Synthetic peptide
Immunogen Sequence: (C)RTNNRTSPRDN, corresponding to amino acid residues 395-405 of human TRPV6
-
亚型
- IgG
-
-
anti-Transient Receptor Potential Cation Channel, Subfamily V, Member 6 (TRPV6) (AA 1-100) antibody
TRPV6 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Transient Receptor Potential Cation Channel, Subfamily V, Member 6 (TRPV6) (Middle Region) antibodyTRPV6 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 马, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Transient Receptor Potential Cation Channel, Subfamily V, Member 6 (TRPV6) (AA 712-725), (Intracellular) antibodyTRPV6 适用: 人 WB, IHC, IP, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Transient Receptor Potential Cation Channel, Subfamily V, Member 6 (TRPV6) (AA 620-764) antibodyTRPV6 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Transient Receptor Potential Cation Channel, Subfamily V, Member 6 (TRPV6) (AA 280-329) antibodyTRPV6 适用: 人, 小鼠, 大鼠, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Transient Receptor Potential Cation Channel, Subfamily V, Member 6 (TRPV6) (AA 578-725) antibodyTRPV6 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:200
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- 0.2 mL double distilled water (DDW).
-
浓度
- 1 mg/mL
-
缓冲液
- PBS pH 7.4
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
-
-
- TRPV6 (Transient Receptor Potential Cation Channel, Subfamily V, Member 6 (TRPV6))
-
别名
- TRPV6
-
背景
-
Epithelial calcium channel 2, ECaC2, Calcium transport protein 1, CaT1, CaT-like, CaT-L, Transient receptor potential cation channel subfamily V member 6,TRP channels are a large family (about 28 genes) of plasma membrane, non-selective cationic channels that are either specifically or ubiquitously expressed in excitable and non-excitable cells.1 According to IUPHAR the TRP family comprises of three main subfamilies on the basis of sequence homology, TRPC, TRPM and TRPV (to date, three extra subfamilies are considered to belong to the TRP family, the TRPA, TRPML, and TRPP).1-4 The TRPV subfamily consists of six members, TRPV1-6.5TRPV6 (CaT1) and TRPV5 (ECaC) are unique members of the TRP family. Both are epithelial calcium channels, form constitutively open channels, share high degree of homology (about 66 % ) with differences in the N and C-terminus. TRPV6 and TRPV5 are expressed in a 1,25-dihydroxyvitamin D3 dependent manner. In contrast to other members of the TRP family, TRPV6 and TRPV5 are highly Ca2+ selective and are expressed in Ca2+ transporting epithelia where they are assumed to have an important role in Ca2+ reabsorption. TRPV6 is highly expressed in the placenta, small intestine and kidney.6,7While not being expressed in benign prostate tissue, TRPV6 was found to be upregulated in prostate cancer tissue and correlation between expression and tumor grade was shown. Finally, TRPV6 was suggested as prognostic marker and as a promising candidate for therapeutic strategies.8,9
Alternative names: TRPV6, Epithelial calcium channel 2, ECaC2, Calcium transport protein 1, CaT1, CaT-like, CaT-L, Transient receptor potential cation channel subfamily V member 6 -
基因ID
- 55503
-
NCBI登录号
- NM_014274
-
UniProt
- Q9H1D0
-
途径
- TCR Signaling
抗原
-
