TSH receptor 抗体 (Extracellular)
Quick Overview for TSH receptor 抗体 (Extracellular) (ABIN7043810)
抗原
See all TSH receptor (TSHR) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 376-390, Extracellular
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原理
- A Rabbit Polyclonal Antibody to TSH Receptor
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特异性
- Extracellular, N-terminus
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse,human - identical
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产品特性
- Anti-TSH Receptor (TSHR) (extracellular) Antibody (ABIN7043810, ABIN7045322 and ABIN7045323) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot analysis. The antibody recognizes an extracellular epitope and thus is ideal for detecting the receptor in living cells. It has been designed to recognize TSHR from human, rat, and mouse samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: ETLQAFDSHYDYTVC, corresponding to amino acid residues 376-390 of rat TSHR
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亚型
- IgG
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anti-Thyroid Stimulating Hormone Receptor (TSHR) (AA 21-253) antibody
TSHR 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Thyroid Stimulating Hormone Receptor (TSHR) (AA 501-600) antibodyTSHR 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Thyroid Stimulating Hormone Receptor (TSHR) (AA 648-740) antibodyTSHR 适用: 人, 小鼠 ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Thyroid Stimulating Hormone Receptor (TSHR) (AA 201-300) antibodyTSHR 适用: 人, 小鼠 ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Thyroid Stimulating Hormone Receptor (TSHR) (AA 28-245) antibodyTSHR 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Thyroid Stimulating Hormone Receptor (TSHR) (C-Term) antibodyTSHR 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Thyroid Stimulating Hormone Receptor (TSHR) (N-Term) antibodyTSHR 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Thyroid Stimulating Hormone Receptor (TSHR) antibodyTSHR 适用: 人 ELISA, IHC, StM, Coat 宿主: 小鼠 Monoclonal TSHRA-1402 unconjugated
anti-Thyroid Stimulating Hormone Receptor (TSHR) antibodyTSHR 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal TSHRB-1405 unconjugated
anti-Thyroid Stimulating Hormone Receptor (TSHR) (Internal Region) antibodyTSHR 适用: 人, 小鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200
Application Dilutions Western blot wb: 1:200
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说明
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Negative Control: (ABIN7237393)
Blocking Peptide: (ABIN7237393)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- TSH receptor (TSHR) (Thyroid Stimulating Hormone Receptor (TSHR))
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别名
- TSHR
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背景
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Thyrotropin receptor, Thyroid-stimulating hormone receptor, TSH-R,Thyroid stimulating hormone (TSH), a glycoprotein hormone composed of α and β chains, is produced by thyrotrope cells of the anterior pituitary1. The TSH receptor (TSHR) plays a prominent role in thyroid physiology and disease. The established biological function of TSHR in the thyroid gland is to regulate synthesis and secretion of thyroid hormones from follicular thyroid cells, it also plays an important role in controlling the growth and development of the thyroid gland2.TSHR is a G-protein coupled receptor and shares the classic structure of the serpentine receptor family (seven membrane spanning segments, an extracellular N-terminus and an intracellular carboxy terminal)3.TSHR is primarily expressed in the epithelial cells of the thyroid follicles, but TSHR mRNA and protein have been detected in a variety of cell types including brain, testes, kidney, heart, bone, thymus, lymphocytes, adipose tissue and fibroblasts4.Chronic stimulation of the TSHR leads to over activation of the cAMP pathway that in turn causes thyroid hyperplasia and hyperthyroidism. This process occurs in Graves' disease (GD) in which thyroid stimulating antibodies (TSAB) bind the receptor and mimic the action of TSH5.
Alternative names: TSH Receptor (TSHR), Thyrotropin receptor, Thyroid-stimulating hormone receptor, TSH-R -
基因ID
- 25360
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NCBI登录号
- NM_000369
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UniProt
- P21463
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途径
- Thyroid Hormone Synthesis
抗原
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