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TSH receptor 抗体 (Extracellular)

Name: TSH receptor 抗体 (Extracellular)
SKU: ABIN7043810
Availability: OutOfStock

TSHR 适用: 大鼠 WB, IHC, IF (cc), LCI 宿主: 兔 Polyclonal unconjugated

Expression of TSH Receptor in mouse hippocampus. (TSH receptor 抗体 (Extracellular))

IHC

Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4) brain lysates: - 1,2. (TSH receptor 抗体 (Extracellular))

Cell surface detection of TSH Receptor by indirect flow cytometry in live intact human THP-1 monocytic leukemia cells: (black line) Cells. (TSH receptor 抗体 (Extracellular))

FACS

3 images

产品编号 ABIN7043810

发货至: 中国

Datasheet as PDF

抗原 See all TSH receptor (TSHR) 抗体

TSH receptor (TSHR) (Thyroid Stimulating Hormone Receptor (TSHR))
抗原表位
16

16

8

5

4

2

1

1

1

1

1

1

1

1

1

1

1
AA 376-390, Extracellular
适用
88

50

32

9

7

5

5

4

4

4

4

3

1

1
大鼠
宿主
71

18

3

1
兔
Compatible Secondaries
克隆类型
72

21
多克隆
标记
49

4

3

3

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1
This TSH receptor antibody is un-conjugated
应用范围
45

45

23

14

13

13

13

8

7

5

4

4

2

2

1

1

1

1

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (Cultured Cells) (IF (cc)), Live Cell Imaging (LCI)

原理

A Rabbit Polyclonal Antibody to TSH Receptor

特异性

Extracellular, N-terminus

交叉反应

人, 小鼠, 大鼠

预测反应

Mouse,human - identical

产品特性

Anti-TSH Receptor (TSHR) (extracellular) Antibody (ABIN7043810, ABIN7045322 and ABIN7045323)) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot analysis. The antibody recognizes an extracellular epitope and thus is ideal for detecting the receptor in living cells. It has been designed to recognize TSHR from human, rat, and mouse samples.

纯化方法

Affinity purified on immobilized antigen.

免疫原

Immunogen: Synthetic peptide
Immunogen Sequence: ETLQAFDSHYDYTVC, corresponding to amino acid residues 376-390 of rat TSHR

亚型

IgG

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anti-Thyroid Stimulating Hormone Receptor (TSHR) (AA 21-253) antibody
TSHR 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Thyroid Stimulating Hormone Receptor (TSHR) (AA 501-600) antibody
TSHR 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Thyroid Stimulating Hormone Receptor (TSHR) (AA 201-300) antibody
TSHR 适用: 人, 小鼠 ELISA, FACS 宿主: 兔 Polyclonal unconjugated

anti-Thyroid Stimulating Hormone Receptor (TSHR) (AA 648-740) antibody
TSHR 适用: 人, 小鼠 ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Thyroid Stimulating Hormone Receptor (TSHR) (AA 28-245) antibody
TSHR 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Thyroid Stimulating Hormone Receptor (TSHR) (C-Term) antibody
TSHR 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Thyroid Stimulating Hormone Receptor (TSHR) (N-Term) antibody
TSHR 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Thyroid Stimulating Hormone Receptor (TSHR) antibody
TSHR 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal TSHRB-1405 unconjugated

anti-Thyroid Stimulating Hormone Receptor (TSHR) antibody
TSHR 适用: 人 ELISA, IHC, StM, Coat 宿主: 小鼠 Monoclonal TSHRA-1402 unconjugated

anti-Thyroid Stimulating Hormone Receptor (TSHR) (Internal Region) antibody
TSHR 适用: 人, 小鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200
Application Dilutions Western blot wb: 1:200

说明

Negative Control: BLP-TR006
Blocking Peptide: BLP-TR006

限制

仅限研究用
状态

Lyophilized

溶解方式

Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.

浓度

1 mg/mL

缓冲液

PBS pH 7.4

储存条件

4 °C,-20 °C

储存方法

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
抗原

TSH receptor (TSHR) (Thyroid Stimulating Hormone Receptor (TSHR))

别名

TSHR (TSHR 产品)

背景

Thyrotropin receptor, Thyroid-stimulating hormone receptor, TSH-R,Thyroid stimulating hormone (TSH), a glycoprotein hormone composed of α and β chains, is produced by thyrotrope cells of the anterior pituitary1. The TSH receptor (TSHR) plays a prominent role in thyroid physiology and disease. The established biological function of TSHR in the thyroid gland is to regulate synthesis and secretion of thyroid hormones from follicular thyroid cells, it also plays an important role in controlling the growth and development of the thyroid gland2.TSHR is a G-protein coupled receptor and shares the classic structure of the serpentine receptor family (seven membrane spanning segments, an extracellular N-terminus and an intracellular carboxy terminal)3.TSHR is primarily expressed in the epithelial cells of the thyroid follicles, but TSHR mRNA and protein have been detected in a variety of cell types including brain, testes, kidney, heart, bone, thymus, lymphocytes, adipose tissue and fibroblasts4.Chronic stimulation of the TSHR leads to over activation of the cAMP pathway that in turn causes thyroid hyperplasia and hyperthyroidism. This process occurs in Graves' disease (GD) in which thyroid stimulating antibodies (TSAB) bind the receptor and mimic the action of TSH5.

Alternative names: TSH Receptor (TSHR), Thyrotropin receptor, Thyroid-stimulating hormone receptor, TSH-R

基因ID

25360

NCBI登录号

NM_000369

UniProt

P21463

途径

Thyroid Hormone Synthesis