TAUT 抗体 (C-Term, Intracellular)
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Quick Overview for TAUT 抗体 (C-Term, Intracellular) (ABIN7043807)
抗原
See all TAUT 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 581-594, C-Term, Intracellular
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原理
- A Rabbit Polyclonal Antibody to Taurine Transporter (SLC6A6)
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse,human - identical
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产品特性
- Anti-Taurine Transporter (SLC6A6) Antibody is directed against an epitope of rat TauT. Anti-Taurine Transporter (SLC6A6) Antibody (ABIN7043807, ABIN7044469 and ABIN7044470) can be used in western blot analysis. It has been designed to recognize TauT from mouse, rat and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)TPREPNRWAVEREG, corresponding to amino acid residues 581-594 of rat TauT
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亚型
- IgG
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anti-Taurine Transporter (TAUT) antibody
TAUT 适用: 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Taurine Transporter (TAUT) (AA 1-49) antibodyTAUT 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Taurine Transporter (TAUT) antibodyTAUT 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Taurine Transporter (TAUT) (AA 250-320) antibodyTAUT 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Taurine Transporter (TAUT) (C-Term) antibodyTAUT 适用: 人, 大鼠, 小鼠, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- TAUT (Taurine Transporter (TAUT))
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别名
- SLC6A6
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背景
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Synonyms: Sodium- and chloride-dependent taurine transporter, TauT
Description: Taurine (2-aminoethane-sulfonice acid) is one of the most abundant amino acids found in the human body. It is involved in cell regulation and modulates the concentration of intracellular free calcium. It also plays a substantial role in many other functions varying from neurotransmission in the central nervous system to promotion of cell differentiation in the brain to cytoprotection against oxidative stress1.Taurine is not used for protein synthesis, and in addition to its uptake in nutrition, it can be synthesized in pancreatic mammalian cells by cysteine dioxygenase and sulfinoalanine decarboxylase enzymes2.Taurine is found mainly in organs such as the brain, retina and muscle tissue.The uptake of taurine is conducted through the taurine transporter (TauT). The energy for passage through the transporter is derived by Na+ and Cl- concentration similar to the uptake of other amino acids3. TauT also transports GABA, albeit with a lower affinity. The transporter has twelve transmembrane domains and intracellular N- and C-termini.TauT expression is regulated by cAMP which was found to increase its regulation in MDCK cells and also by PKC via means of post-translational modification. PKC activation leads to reduced taurine transport4. PKC is believed to phosphorylate the highly conserved serine-322 position in the transporter.Taurine deficiency is linked to cardiomyopathies in the hearts of cats and to a decrease in cardiac muscle sensitivity to calcium5 and better understanding of its transport may improve research of these diseases.
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基因ID
- 29464
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NCBI登录号
- NM_003043
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UniProt
- P31643
抗原
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