TACR1 抗体 (Extracellular) (Atto 488)
Quick Overview for TACR1 抗体 (Extracellular) (Atto 488) (ABIN7043804)
抗原
See all TACR1 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 180-194, Extracellular
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原理
- A Rabbit Polyclonal Antibody to Neurokinin 1 Receptor Conjugated to the Fluorescent Dye ATTO-488
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特异性
- 2nd extracellular loop
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse - identical, human - 13,15 amino acid residues identical
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产品特性
- Anti-Neurokinin 1 Receptor (NK1R) (extracellular) Antibody (ABIN7043803, ABIN7045318 and ABIN7045319) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot, indirect live cell flow cytometry, and live cell imaging applications. It has been designed to recognize NK1 receptor from rat, mouse, and human samples. \nAnti-Neurokinin 1 Receptor (NK1R) (extracellular)-ATTO Fluor-488 Antibody (ABIN7043804) is directly labeled with an fluorescent dye. ATTO dyes are characterized by strong absorption (high extinction coefficient), high fluorescence quantum yield, and high photo-stability. The label is analogous to the well known dye fluorescein isothiocyanate (FITC) and can be used with filters typically used to detect FITC. Anti-Neurokinin 1 Receptor (NK1R) (extracellular)-ATTO Fluor-488 Antibody is especially suited for experiments requiring simultaneous labeling of different markers.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: CMIEWPEHPNRTYEK, corresponding to amino acid residues 180-194 of rat NK1 receptor
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亚型
- IgG
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anti-Tachykinin Receptor 1 (TACR1) (AA 2-50) antibody
TACR1 适用: 人, 大鼠 WB, ELISA, IHC (p), IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Tachykinin Receptor 1 (TACR1) (C-Term) antibodyTACR1 适用: 人, 大鼠, 豚鼠, 猴, 马, 兔, Hamster IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Tachykinin Receptor 1 (TACR1) (Internal Region) antibodyVerified TACR1 适用: 人, 小鼠 WB, ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-Tachykinin Receptor 1 (TACR1) (AA 180-194), (Extracellular) antibodyTACR1 适用: 大鼠 WB, IHC, FACS, LCI, IC 宿主: 兔 Polyclonal unconjugated
anti-Tachykinin Receptor 1 (TACR1) (AA 1-29) antibodyTACR1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Tachykinin Receptor 1 (TACR1) (AA 140-243) antibodyTACR1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Tachykinin Receptor 1 (TACR1) (Extracellular Domain) antibodyTACR1 适用: 人, 犬, 猴, Cow IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Tachykinin Receptor 1 (TACR1) antibodyMicroarray verified TACR1 适用: 人 IHC 宿主: 小鼠 Monoclonal MAB139563 unconjugated
anti-Tachykinin Receptor 1 (TACR1) antibodyMicroarray verified TACR1 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal MAB323175 unconjugated
anti-Tachykinin Receptor 1 (TACR1) (Internal Region) antibodyTACR1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:60-1:100
Application Dilutions Western blot wb: N/A
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说明
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Cited Application: FC
Negative Control: (ABIN7582041)
Blocking Peptide: (ABIN7237370)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 50 μL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- TACR1 (Tachykinin Receptor 1 (TACR1))
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别名
- TACR1
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背景
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NK1 receptor, Tachykinin receptor 1, TACR1, Substance-P receptor, SPR,Substance P (SP), Neurokinin A (NKA) and Neurokinin B (NKB) are all peptides belonging to the Tachykinin protein family. These three peptides, which demonstrate quite a heterogeneity in their distribution, exert their effect via three receptors: Neurokinin 1-3 receptors, members of the G-protein coupled receptor superfamily. However, Neurokinin 1 (NK1) receptor preferentially binds Substance P, Neurokinin 2 (NK2) receptor to NKA, and Neurokinin 3 (NK3) receptor to NKB1.Neurokinin receptors are distinguished by their seven transmembrane domains, an extracellular N-terminus and a cytosolic C-terminal. An unusual property of these receptors is the presence of introns as part of their structural organization1-3. Tachykinin receptors undergo alternative splicing. For example, NK1 receptor is detected with different C-terminal lengths. The longer receptor isoform is found in the brain whereas the truncated form is mostly detected in the periphery1,4.Due to the broad expression profile of tachykinin peptides, their respective receptors are also expressed in a similar fashion. NK1 receptor is widely expressed in neurons, endothelial cells, muscle and immune system cells. NK2 receptor is broadly expressed in the periphery and its expression in the brain is quite restricted. NK3 receptor on the other hand is largely expressed in the central nervous system and is also detected in the uterus, skeletal muscle, lung and liver1.Neurokinin receptors have been found in many pathophysiological indications and have therefore become targets for the development of pharmacological compounds. Such indications include cancer, psychological disorders, migraine and various inflammations, just to name a few5-8.
Alternative names: Neurokinin 1 Receptor (NK1R), NK1 receptor, Tachykinin receptor 1, TACR1, Substance-P receptor, SPR -
基因ID
- 24807
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NCBI登录号
- NM_001058
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UniProt
- P14600
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途径
- Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour, Smooth Muscle Cell Migration
抗原
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