SNCA 抗体 (C-Term, Intracellular)
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Quick Overview for SNCA 抗体 (C-Term, Intracellular) (ABIN7043800)
抗原
See all SNCA 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 97-110, C-Term, Intracellular
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原理
- A Guinea Pig Polyclonal Antibody to α-Synuclein
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交叉反应
- 小鼠, 大鼠
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预测反应
- Mouse - identical, human - 11 out of 14 amino acid residues identical
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产品特性
- Guinea Pig Anti-Alpha-Synuclein Antibody is a highly specific antibody directed against an epitope of rat α-Synuclein (SNCA). The antibody can be used in western blot analysis and immunohistochemistry applications. It has been designed to recognize α-Synuclein from rat, mouse and human samples. The antigen used to immunize guinea pigs is the same as Anti-Alpha-Synuclein Antibody (ABIN7043799, ABIN7045180 and ABIN7045181) raised in rabbit. Our line of guinea pig antibodies enables more flexibility with our products such as multiplex staining studies, immunoprecipitation and more.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)KDQMGKGEEGYPQE, corresponding to amino acid residues 97-110 of rat alpha-synuclein
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亚型
- IgG
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anti-Synuclein, alpha (SNCA) (pSer129) antibody
SNCA 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (PerCP)SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 PerCP
anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (PE)SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 PE
anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (Atto 488)SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 Atto 488
anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (Atto 390)SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 Atto 390
anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (Atto 594)SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 Atto 594
anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (Biotin)SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 Biotin
anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (FITC)SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 FITC
anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (APC)SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 APC
anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (HRP)SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 HRP
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应用备注
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WB: 1:400
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:300
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7237358)
Blocking Peptide: (ABIN7237358)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- SNCA (Synuclein, alpha (SNCA))
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别名
- SNCA
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背景
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Synonyms: α-Synuclein, Non-A4 component of amyloid precursor, Parkinson disease (autosomal dominant, Lewy body) 4, PARK1, PARK4, NACP, SNCA
Description: α-Synuclein belongs to the Synuclein family of proteins containing three other members (β-synuclein, γ-synuclein and synoretnin). α-Synuclein is a highly conserved acidic protein that is concentrated mainly in presynaptic axon terminals.The gene encoding α-synuclein is known as SNCA or PARK1. α-Synuclein, together with other members of its family, lacks typical secondary structure. In its primary structure, α-synuclein is characterized by seven imperfect 11-residue repeat sequences that are predicted to form five amphipatic helices on the amino terminal half. The acidic, glutamate rich carboxy-terminal region remains unstructured even in the presence of membranes. α-Synuclein helices 1-4 are predicted to associate with lipid vesicles while helix 5 would be responsible for protein-to-protein interaction. The protein interacts and with DAT, the dopamine transporter, and thus is involved in dopamine signaling. Under pathological conditions, α-synuclein can undergo conformational changes leading to protein aggregation and deposition.α-Synuclein shares structural homology with the 14-3-3 family of chaperon proteins and its expression is upregulated during periods of accelerated neuronal activity and plasticity thus suggesting it might be functioning as a molecular chaperon capable of binding to other intercellular proteins.α-Synuclein has been implicated in the pathophysiology of Parkinson's disease (PD) and Lewy body dementia (DLB). Mutations A30P and A3T are associated with PD while mutation E46K has been linked to DLB. These mutated α-synucleins form fibrils more rapidly than the wild-type protein in aqueous solution1. α-Synucleins are the major components of Lewy bodies and Lewy neurites in both diseases2.
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基因ID
- 29219
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NCBI登录号
- NM_000345
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UniProt
- P37377
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途径
- Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity
抗原
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