SNTA1 抗体 (Intracellular)
Our Local Distributor
北京 101111
Quick Overview for SNTA1 抗体 (Intracellular) (ABIN7043797)
抗原
See all SNTA1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 191-205, Intracellular
-
原理
- A Rabbit Polyclonal Antibody to α1-Syntrophin (SNTA1)
-
特异性
- Intracellular, PH1 domain
-
交叉反应
- 人, 小鼠, 大鼠
-
预测反应
- Mouse,human - identical
-
产品特性
- Anti-alpha1-Syntrophin (SNTA1) Antibody is directed against an epitope of mouse syntrophin alpha 1. Anti-α1-Syntrophin (SNTA1) Antibody (ABIN7043797, ABIN7045164 and ABIN7045165) can be used in western blot and immunohistochemistry applications. It has been designed to recognize syntrophin alpha 1 from mouse, rat and human samples.
-
纯化方法
- Affinity purified on immobilized antigen.
-
免疫原
-
Immunogen: Synthetic peptide
Immunogen Sequence: (C)RQPSSPGPQPRNLSE, corresponding to amino acid residues 191-205 of mouse alpha1-syntrophin
-
亚型
- IgG
-
-
anti-Syntrophin, alpha 1 (Dystrophin-Associated Protein A1, 59kDa, Acidic Component) (SNTA1) antibody
SNTA1 适用: 人, 大鼠, 犬, 猴 WB, IF, FACS 宿主: 小鼠 Monoclonal 1H10 unconjugated
anti-Syntrophin, alpha 1 (Dystrophin-Associated Protein A1, 59kDa, Acidic Component) (SNTA1) antibodySNTA1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Syntrophin, alpha 1 (Dystrophin-Associated Protein A1, 59kDa, Acidic Component) (SNTA1) antibodySNTA1 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Syntrophin, alpha 1 (Dystrophin-Associated Protein A1, 59kDa, Acidic Component) (SNTA1) antibodySNTA1 适用: 人, 大鼠, 犬, 猴 WB, IF, FACS 宿主: 小鼠 Monoclonal 2E12 unconjugated
anti-Syntrophin, alpha 1 (Dystrophin-Associated Protein A1, 59kDa, Acidic Component) (SNTA1) antibodySNTA1 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB4150 unconjugated Recombinant Antibody
anti-Syntrophin, alpha 1 (Dystrophin-Associated Protein A1, 59kDa, Acidic Component) (SNTA1) antibodySNTA1 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Syntrophin, alpha 1 (Dystrophin-Associated Protein A1, 59kDa, Acidic Component) (SNTA1) (AA 1-505) antibodySNTA1 适用: 人 WB, IF, ELISA, ICC 宿主: 小鼠 Monoclonal AT1E1 unconjugated
anti-Syntrophin, alpha 1 (Dystrophin-Associated Protein A1, 59kDa, Acidic Component) (SNTA1) (N-Term) antibodyVerified SNTA1 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Syntrophin, alpha 1 (Dystrophin-Associated Protein A1, 59kDa, Acidic Component) (SNTA1) (AA 191-505) antibodySNTA1 适用: 人 WB, IHC, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:400
Application Dilutions Western blot wb: 1:200-1:400
-
说明
-
Negative Control: (ABIN7237350)
Blocking Peptide: (ABIN7237350)
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
-
浓度
- 1 mg/mL
-
缓冲液
- PBS pH 7.4
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
-
-
- SNTA1 (Syntrophin, alpha 1 (Dystrophin-Associated Protein A1, 59kDa, Acidic Component) (SNTA1))
-
别名
- SNTA1
-
背景
-
Syntrophin alpha 1, Syntrophin-1, 59 kDa dystrophin-associated protein A1 acidic component 1,α1-Syntrophin is a component of the dystrophin scaffold-protein complex that acts in recruiting proteins through their multiple protein-protein interaction motifs to the cytoplasmic side of plasma membranes. Proteins interacting with α1-syntrophin include voltage-gated sodium channels, neuronal nitric oxide synthase, calmodulin, ankyrin repeat-rich membrane spanning protein, G-proteins and more. The syntrophin family comprises five members: α1-syntrophin, β1-syntrophin, β2-syntrophin, γ1-syntrophin, and γ2-syntrophin1.α1-Syntrophin is a peripheral cytoplasmic membrane protein in skeletal and cardiac muscle cells1.The α1-syntrophin structure contains four conserved domains, two pleckstrin homology domains (PH1 and PH2), a PSD95-disks large-ZO1 (PDZ) domain and a syntrophin unique (SU) COOH-terminal domain2. The pleckstrin domains are responsible for the recruitment of proteins to the sarcolemma. The PDZ domain is inserted within the PH1 domain and binds to NOS-1 in skeletal muscle. This domain also binds to the C-terminus of the Kir2.1 channel and also to NaV1.5 and so allowing them to interact. The SU domain binds syntrophin to dystrophin2,3. α1-Syntrophin is also responsible for the site-specific anchoring of AQP4 protein. α1-Syntrophin deletion leads to the disruption of the polarized subcellular expression of AQP4 in the perivascular membranes4. Several studies have shown that syntrophin-deficiency in Duchenne muscular dystrophy can ultimately lead to muscle degeneration. Syntrophin-deficiency was also shown to reduce levels of nNOS in mice5,6.
Alternative names: alpha1-Syntrophin (SNTA1), Syntrophin alpha 1, Syntrophin-1, 59 kDa dystrophin-associated protein A1 acidic component 1 -
基因ID
- 20648
-
NCBI登录号
- NM_003098
-
UniProt
- Q61234
-
途径
- Synaptic Membrane, Skeletal Muscle Fiber Development
抗原
-
