SYN2 抗体 (Domain G, Intracellular)
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Quick Overview for SYN2 抗体 (Domain G, Intracellular) (ABIN7043787)
抗原
See all SYN2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 438-450, Domain G, Intracellular
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原理
- A Rabbit Polyclonal Antibody to Synapsin II
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交叉反应
- 小鼠, 大鼠
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交叉反应 （详细）
- This antibody will recognize both canonical isoforms (also known as Synapsin IIa) and the shorter isoform (Synapsin-IIb).
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预测反应
- Mouse - identical, human- 12,13 amino acid residues identical
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产品特性
- Anti-Synapsin II (SYN2) Antibody (ABIN7043787, ABIN7044660 and ABIN7044661) is a highly selective antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize Synapsin II from mouse, human, and rat samples. This antibody will recognize both canonical isoforms (also known as Synapsin IIa) and the shorter isoform (Synapsin IIb).
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)SGTLKEPDSSKTP, corresponding to amino acid residues 438-450 of rat Synapsin-2
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亚型
- IgG
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anti-Synapsin II (SYN2) (AA 497-582) antibody
SYN2 适用: 小鼠, 人, 大鼠, Pig WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Synapsin II (SYN2) antibodySYN2 适用: 小鼠, 人, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Synapsin II (SYN2) antibodyKO Validated SYN2 适用: 小鼠, 人, 大鼠 WB, IHC, IP, ICC, IHC (p) 宿主: 小鼠 Monoclonal 27E3 unconjugated
anti-Synapsin II (SYN2) antibodySYN2 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB4960 unconjugated Recombinant Antibody
anti-Synapsin II (SYN2) antibodySYN2 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB4660 unconjugated Recombinant Antibody
anti-Synapsin II (SYN2) (AA 88-422) antibodySYN2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Synapsin II (SYN2) antibodyKO Validated SYN2 适用: 小鼠, 人, 大鼠, Pig WB, IHC, IP, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Synapsin II (SYN2) (AA 348-448) antibodySYN2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:200
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7237311)
Blocking Peptide: (ABIN7237311)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- SYN2 (Synapsin II (SYN2))
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别名
- SYN2
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背景
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Synonyms: Synapsin-2
Description: Synapsins are a family of ten homologous neuronal phosphoproteins evolutionarily conserved in invertebrate and vertebrate organisms. Synapsins appear to be crucial determinants for the fine-tuning of synaptic transmission and for synaptic remodeling. This is particularly evident in several paradigms of short-term plasticity (STP), which are specifically affected by mutations or malfunctioning of synapsin proteins. Notably, knockout of synapsin-2 in mice causes fully generalized forebrain seizures from the age of 2 months1.All synapsins, including synapsin-2, are composed of a highly homologous N-terminal region, and a more variable C-terminus. The N-terminal homologous region can be divided in three domains, namely domain A, B and C, which, except for domain B, are highly conserved across isoforms and species. Domain A is contains the phosphorylation site for PKA and CaMKI. Domain B, rich in small amino acids, is considered as a linker region connecting domain A to domain C. Domain C is a large region of about 300 amino acids, containing both hydrophobic and highly charged sequences with the potential to assume α-helix and β-sheet conformations. It shows extensive homology amongst the various members of the family, and mediates the core functions of synapsins1.
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基因ID
- 29179
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NCBI登录号
- NM_133625
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UniProt
- Q63537
抗原
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