SUCNR1 抗体 (Extracellular) (FITC)
Quick Overview for SUCNR1 抗体 (Extracellular) (FITC) (ABIN7043784)
抗原
See all SUCNR1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 248-262, Extracellular
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原理
- A Rabbit Polyclonal Antibody to GPR91 Conjugated to the Fluorescent Dye FITC
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特异性
- 3rd extracellular loop
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- 15 amino acid residues identical,Mouse - 14, human - 12
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产品特性
- Anti-GPR91 (SUCNR1) (extracellular) Antibody (ABIN7043783, ABIN7045308 and ABIN7045309) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and live cell flow cytometry. It has been designed to recognize GPR91 from rat, mouse, and human samples. \nAnti-GPR91 (SUCNR1) (extracellular)-FITC Antibody (ABIN7043783, ABIN7045308 and ABIN7045309)-F) is directly conjugated to fluorescein isothiocyanate (FITC). The antibody can be used in immunofluorescent applications such as direct live cell flow cytometry.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)RNVRIASRLDSWPQG, corresponding to amino acid residues 248-262 of rat GPR91
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亚型
- IgG
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anti-Succinate Receptor 1 (SUCNR1) (AA 303-334) antibody
SUCNR1 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Succinate Receptor 1 (SUCNR1) (Cytoplasmic Domain) antibodySUCNR1 适用: 人 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Succinate Receptor 1 (SUCNR1) (Internal Region) antibodySUCNR1 适用: 人, 大鼠, 小鼠 ELISA, WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Succinate Receptor 1 (SUCNR1) (AA 248-262), (Extracellular) antibodySUCNR1 适用: 大鼠 WB, IHC, FACS, LCI 宿主: 兔 Polyclonal unconjugated
anti-Succinate Receptor 1 (SUCNR1) (Cytoplasmic Domain) antibodySUCNR1 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Succinate Receptor 1 (SUCNR1) (AA 100-149) antibodySUCNR1 适用: 人, 大鼠, 小鼠 ELISA, WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Succinate Receptor 1 (SUCNR1) antibodySUCNR1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Succinate Receptor 1 (SUCNR1) (AA 161-210) antibodySUCNR1 适用: 人, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Succinate Receptor 1 (SUCNR1) antibodySUCNR1 适用: 人, 大鼠, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: N/A
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说明
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Cited Application: FC
Negative Control: (ABIN7582044)
Blocking Peptide: (ABIN7237300)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 15 μL or 50 μL double distilled water (DDW), depending on the sample size.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- SUCNR1 (Succinate Receptor 1 (SUCNR1))
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别名
- SUCNR1
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背景
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G-protein coupled receptor 91, Succinate receptor 1,GPR91 (Succinate Receptor 1), a member of the GPCR superfamily, is specifically activated by extracellular succinate outside the tricarboxylic acid cycle, resulting in activation of paracrine and endocrine effectors. Activation of GPR91 is associated with several diseases, including hypertension and diabetes1,2.GPR91 was shown to regulate normal retinal vascularization, proliferative ischemic retinopathy and cortical revascularization post-ischemia. Activation of GPR91 influences different tissues such as kidney, heart, retina, white adipose tissue, and liver.Through the activation of GPR91, succinate affects motility, migration, and growth of dendritic cells. In addition, the receptor directly promotes chemotaxis and potentiates activation initiated by Toll-like receptor agonists in dendritic cells1-3.In the heart GPR91 mediates succinate-induced cardiomyocyte death. It was demonstrated that upholding levels of serum succinate can cause cardiac hypertrophy through the activation of the GPR911,2.
Alternative names: GPR91 (SUCNR1), G-protein coupled receptor 91, Succinate receptor 1 -
基因ID
- 408199
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NCBI登录号
- NM_033050
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UniProt
- Q6IYF9
抗原
-
