STOML1 抗体 (Extracellular, N-Term)
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Quick Overview for STOML1 抗体 (Extracellular, N-Term) (ABIN7043778)
抗原
See all STOML1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 4-17, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to Stomatin-Like Protein 1
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Rat,human - identical
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产品特性
- Anti-Stomatin-like Protein 1 (extracellular) Antibody (ABIN7043778, ABIN7044516 and ABIN7044517) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot analysis. The antibody recognizes an extracellular epitope and can potentially be used for detecting the protein in living cells. It has been designed to recognize STOML1 from human, mouse, and rat samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)RSGYRALPLGDFDR, corresponding to amino acid residues 4-17 of mouse STOML1
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亚型
- IgG
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anti-Stomatin (EPB72)-Like 1 (STOML1) antibody
STOML1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Stomatin (EPB72)-Like 1 (STOML1) (AA 1-398) antibodySTOML1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Stomatin (EPB72)-Like 1 (STOML1) (AA 107-206) antibodySTOML1 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
anti-Stomatin (EPB72)-Like 1 (STOML1) (AA 79-290) antibodySTOML1 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Stomatin (EPB72)-Like 1 (STOML1) (AA 1-30), (N-Term) antibodySTOML1 适用: 人 WB 宿主: 兔 Polyclonal RB37368 unconjugated
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应用备注
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WB: 1:500-1:800
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7237284)
Blocking Peptide: (ABIN7237284)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- STOML1 (Stomatin (EPB72)-Like 1 (STOML1))
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别名
- STOML1
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背景
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Synonyms: STOML1, SLP-1, STORP, Slipin-1, hUNC-24
Description: The Stomatin-like protein family contains five members and are characterized by the presence of a structurally conserved core called the stomatin-domain. This stomatin-domain is further related to a domain found in members of the prohibitin, flotillin and HflK/HflC protein families and has accordingly also been called the SPFH domain.All mammalian stomatin proteins are integral membrane protein with a single, relatively short, hydrophobic membrane insertion domain, followed by the core stomatin-domain. A single conserved proline residue (known to be a potent helix breaker) in the hydrophobic region is required for the formation of the protein's hairpin structure. The N-terminal domain is extracellular. Stomatin-like protein 1 (STOML1) has a typical stomatin-domain at the N-terminus and an additional sterol carrier protein-2 (SCP-2) domain at the C-terminus. STOML-1 is targeted to the late endosomal compartment where it interacts with stomatin. STOML-1 is predominantly expressed in the brain, in a subpopulation of sensory neurons in the dorsal root ganglia. Much lower levels are detected in other tissues1.Following anoxia, STOML-1 expression is up-regulated by the oxidative response factor SKN-1/Nrf. SKN-1/Nrf is required for both rapid mitochondrial refusion and rapid behavioral recovery during reoxygenation suggesting that STOML-1 helps facilitate mitochondrial dynamics following anoxia2.STOML-1 also modulates the proton-sensitive members of the acid-sensing ion channel (ASIC) family. STOML-1 strongly inhibits ASIC1a and accelerates the inactivation time constant of ASIC3, but has no effect on the splice variant ASIC1b3.
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基因ID
- 69106
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NCBI登录号
- NM_004809
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UniProt
- Q8CI66
抗原
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