SSTR4 抗体 (Extracellular)
Quick Overview for SSTR4 抗体 (Extracellular) (ABIN7043766)
抗原
See all SSTR4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 182-194, Extracellular
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原理
- A Rabbit Polyclonal Antibody to Somatostatin Receptor Type 4
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特异性
- 2nd extracellular loop
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交叉反应
- 小鼠, 大鼠
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预测反应
- Mouse - identical, human - 12,13 amino acid residues identical
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产品特性
- Anti-Somatostatin Receptor Type 4 (extracellular) Antibody (ABIN7043766, ABIN7045265 and ABIN7045266) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize SSTR4 from rat, mouse, and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: DTRPARGGEAVAC, corresponding to amino acid residues 182-194 of rat SSTR4
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亚型
- IgG
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anti-Somatostatin Receptor 4 (SSTR4) (AA 314-388) antibody
SSTR4 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Somatostatin Receptor 4 (SSTR4) (C-Term) antibodySSTR4 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Somatostatin Receptor 4 (SSTR4) (AA 163-212) antibodySSTR4 适用: 人, 小鼠, 兔, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:200
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说明
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Negative Control: (ABIN7237247)
Blocking Peptide: (ABIN7237247)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- SSTR4 (Somatostatin Receptor 4 (SSTR4))
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别名
- SSTR4
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背景
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SSTR4, SS4R, Smstr4,Somatostatin (SST) is a small cyclic peptide that was first identified as a powerful inhibitor of the secretion of various hormones including growth hormone (GH), thyroid-stimulating hormone (TSH) and prolactin from the pituitary, as well as almost every major hormone from the intestinal tract. SST consists of two major bioactive forms, SST-14 and the N-terminus extended peptide SST-28 that can be produced by a wide variety of neuroendocrine, inflammatory and immune cells. In target cells, SST induces a variety of physiological functions that include neuromodulation, cell secretion, cell proliferation and smooth muscle contractility.SST acts on its multiple cell targets via a family of six receptors that originate from five genes: SSTR1, SSTR2a, SSTR2b, SSTRR3, SSTR4, SSTR5. The SSTRs are members of the G-protein coupled receptor superfamily and they modulate cell responses via multiple second messenger systems such as inhibition of adenylate cyclase, modulation of conductance of ion channels and protein dephosphorylation.SSTRs are expressed widely in both the brain and peripheral tissues but with receptor subtype variations between the different cell types. SSTR4 is the SSTR subtype least expressed in the brain but is most strongly expressed in the lung, heart and placenta.Strong SSTR expression has been detected in a variety of human tumors including pancreatic, breast, lung and prostate cancers. In fact, SST has been shown to inhibit the growth of various normal and tumor cells. On this basis, several long lasting SST analogs have been developed and are being tested for use in several pathologies such as various cancers, acromegaly, immunoproliferative disorders, diabetic retinopathy, epilepsy and pain.
Alternative names: Somatostatin Receptor Type 4, SSTR4, SS4R, Smstr4 -
基因ID
- 25555
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NCBI登录号
- NM_001052
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UniProt
- P30937
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途径
- cAMP Metabolic Process
抗原
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