SLC38A1 抗体 (Cytosolic)
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- 抗原 See all SLC38A1 抗体
- SLC38A1 (Solute Carrier Family 38 Member 1 (SLC38A1))
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抗原表位
- AA 41-57, Cytosolic
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适用
- 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SLC38A1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 原理
- A Rabbit Polyclonal Antibody to SLC38A1 Transporter
- 特异性
- Cytoplasmic, N-terminus
- 交叉反应
- 人, 小鼠, 大鼠
- 预测反应
- Mouse,human - identical
- 产品特性
- Anti-SLC38A1 Antibody (ABIN7043722, ABIN7044857 and ABIN7044858) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot analysis. It has been designed to recognize SNAT1 from human, rat, and mouse samples.
- 纯化方法
- Affinity purified on immobilized antigen.
- 免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)SKFISDRESRRSLTNSH, corresponding to amino acid residues 41-57 of rat SLC38A1
- 亚型
- IgG
- Top Product
- Discover our top product SLC38A1 Primary Antibody
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- 应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200
Application Dilutions Western blot wb: 1:200-1:500
- 说明
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Negative Control: (ABIN7237083)
Blocking Peptide: (ABIN7237083)
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- 抗原
- SLC38A1 (Solute Carrier Family 38 Member 1 (SLC38A1))
- 别名
- SLC38A1 (SLC38A1 产品)
- 背景
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Sodium-coupled neutral amino acid transporter 1, Snat1, Amino acid transporter A1, rATA1, Glutamine transporter, N-system amino acid transporter 2, Ata1, Glnt, Sa2, Sat1,SNAT1 (SLC38A1, Sodium-coupled neutral amino acid transporter 1) is a 486 amino acids system A type sodium symporter that catalyzes the electrogenic Na+-dependent uptake of glutamine, among other substrates. SNAT1 is thought to be responsible for glutamine uptake into neurons1.SNAT1 belongs to the β-family of solute carriers that includes three SLC families, SLC32, SLC36, and SLC38. SNAT1 is a member of the SLC38 family that includes 11 members, SNAT1 to SNAT11.SNAT1 and SNAT2 are expressed in neurons and in glial cells all over the central nervous system, with high expression in perivascular glial profiles and lower expression in astrocytes of the cerebral parenchyma. This supports a role in controlling the amino acid permeability at the blood-brain barrier2. SNAT1 also acts as a positive regulator of mTORC1 signaling pathway in neurons and plays an important pathological role in the mechanism underlying neuronal survival after ischemia3. It was also shown to be up-regulated in specific types of cancer4.The structure of SNAT proteins is predicted to have a 5+5 inverted repeat fold typical of the bacterial LeuT, with intracellular N-terminus and extracellular and C-terminal tail5.
Alternative names: Sodium-coupled neutral amino acid transporter 1, Snat1, Amino acid transporter A1, rATA1, Glutamine transporter, N-system amino acid transporter 2, Ata1, Glnt, Sa2, Sat1 - 基因ID
- 170567
- NCBI登录号
- NM_001077484
- UniProt
- Q9JM15
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