NALCN 抗体 (Domain 3, Extracellular)
Our Local Distributor
北京 101111
Quick Overview for NALCN 抗体 (Domain 3, Extracellular) (ABIN7043658)
抗原
See all NALCN 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 902-914, Domain 3, Extracellular
-
原理
- A Rabbit Polyclonal Antibody to Sodium Leak Channel Non-Selective Protein (NALCN)
-
交叉反应
- 人, 小鼠, 大鼠
-
预测反应
- Mouse,human - identical
-
产品特性
- Anti-NALCN/VGCNL1 (extracellular) Antibody (ABIN7043658 and ABIN7045249) is a highly specific antibody directed against an epitope of rat Sodium leak channel non-selective protein. The antibody can be used in western blot, immunohistochemistry and live cell imaging applications. It has been designed to recognize NALCN from mouse, rat, and human samples.
-
纯化方法
- Affinity purified on immobilized antigen.
-
免疫原
- (C)SMMFESPFRRVMH, corresponding to amino acid residues 902-914 of rat NALCN
-
亚型
- IgG
-
-
anti-Sodium Leak Channel, Non-Selective (NALCN) (AA 1659-1738) antibody (Biotin)
NALCN 适用: 大鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S187-7 Biotin
anti-Sodium Leak Channel, Non-Selective (NALCN) (AA 1659-1738) antibody (FITC)NALCN 适用: 大鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S187-7 FITC
anti-Sodium Leak Channel, Non-Selective (NALCN) (AA 1659-1738) antibody (Atto 488)NALCN 适用: 大鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S187-7 Atto 488
anti-Sodium Leak Channel, Non-Selective (NALCN) (AA 1659-1738) antibody (Atto 594)NALCN 适用: 大鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S187-7 Atto 594
anti-Sodium Leak Channel, Non-Selective (NALCN) (AA 1659-1738) antibody (Atto 390)NALCN 适用: 大鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S187-7 Atto 390
anti-Sodium Leak Channel, Non-Selective (NALCN) (AA 1659-1738) antibody (PE)NALCN 适用: 大鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S187-7 PE
anti-Sodium Leak Channel, Non-Selective (NALCN) (AA 1659-1738) antibody (PerCP)NALCN 适用: 大鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S187-7 PerCP
anti-Sodium Leak Channel, Non-Selective (NALCN) (AA 1659-1738) antibody (APC)NALCN 适用: 大鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S187-7 APC
anti-Sodium Leak Channel, Non-Selective (NALCN) (AA 1659-1738) antibody (HRP)NALCN 适用: 大鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S187-7 HRP
anti-Sodium Leak Channel, Non-Selective (NALCN) (AA 1659-1738) antibodyNALCN 适用: 大鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S187-7 unconjugated
-
-
应用备注
-
WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: 1:50
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
-
说明
-
Negative Control: (ABIN7236886)
Blocking Peptide: (ABIN7236886)
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
-
浓度
- 0.8 mg/mL
-
缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
-
-
- NALCN (Sodium Leak Channel, Non-Selective (NALCN))
-
别名
- NALCN
-
背景
-
Synonyms: Sodium leak channel non-selective protein, Voltage gated channel-like protein 1, Four domain-type voltage-gated ion channel alpha-1 subunit, CanIon, Rb21-channel
Description: The existence of resting K+ conductance has been known for some time. Only recently has the Nalcn (sodium leak channel non-selective protein) been found responsible for the resting Na+ conductance1.Nalcn is a member of the NaV and CaV channel family which have four homologous repeats of six transmembrane domains. One structural difference is that Nalcn is less positively charged in the voltage sensing segment1. The protein forms voltage-independent non-inactivating channel which is permeable to Na+, K+ and Ca2+ ions1,2.Evidence suggests that Nalcn is a non-redundant and thus essential channel since knock-out mice display disrupted respiratory rhythm and die within 24 hours of birth. In addition, isolated neurons from these mice have decreased excitability1.The channel is extensively expressed in the central nervous system1, heart, pituitary and adrenal glands and pancreatic islet cells2,3.In pancreatic islets, Nalcn is activated by acetylcholine via its physical association with M3 muscarinic receptor, and potentiates insulin secretion induced by glucose uptake2-4.
-
基因ID
- 266760
-
NCBI登录号
- NM_052867
-
UniProt
- Q6Q760
抗原
-
