NALCN 抗体 (Extracellular)
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- 抗原 See all NALCN 抗体
- NALCN (Sodium Leak Channel, Non-Selective (NALCN))
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抗原表位
- AA 902-914, Extracellular
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适用
- 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This NALCN antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunochromatography (IC), Live Cell Imaging (LCI)
- 原理
- A Rabbit Polyclonal Antibody to Sodium Leak Channel Non-Selective Protein (NALCN)
- 特异性
- Extracellular, S1-S2 domain III.
- 交叉反应
- 人, 小鼠, 大鼠
- 预测反应
- Mouse,human - identical
- 产品特性
- Anti-NALCN/VGCNL1 (extracellular) Antibody (ABIN7043658 and ABIN7045249) is a highly specific antibody directed against an epitope of rat Sodium leak channel non-selective protein. The antibody can be used in western blot, immunohistochemistry and live cell imaging applications. It has been designed to recognize NALCN from mouse, rat, and human samples.
- 纯化方法
- Affinity purified on immobilized antigen.
- 免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)SMMFESPFRRVMH, corresponding to amino acid residues 902-914 of rat NALCN
- 亚型
- IgG
- Top Product
- Discover our top product NALCN Primary Antibody
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anti-Sodium Leak Channel, Non-Selective (NALCN) (AA 1659-1738) antibody
NALCN 适用: 大鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S187-7 unconjugated
anti-Sodium Leak Channel, Non-Selective (NALCN) (AA 1659-1738) antibody (HRP)NALCN 适用: 大鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S187-7 HRP
anti-Sodium Leak Channel, Non-Selective (NALCN) (AA 1659-1738) antibody (PE)NALCN 适用: 大鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S187-7 PE
anti-Sodium Leak Channel, Non-Selective (NALCN) (AA 1659-1738) antibody (FITC)NALCN 适用: 大鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S187-7 FITC
anti-Sodium Leak Channel, Non-Selective (NALCN) (AA 1659-1738) antibody (APC)NALCN 适用: 大鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S187-7 APC
anti-Sodium Leak Channel, Non-Selective (NALCN) (AA 1659-1738) antibody (Atto 488)NALCN 适用: 大鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S187-7 Atto 488
anti-Sodium Leak Channel, Non-Selective (NALCN) (AA 1659-1738) antibody (Biotin)NALCN 适用: 大鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S187-7 Biotin
anti-Sodium Leak Channel, Non-Selective (NALCN) (AA 1659-1738) antibody (PerCP)NALCN 适用: 大鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S187-7 PerCP
anti-Sodium Leak Channel, Non-Selective (NALCN) (AA 1659-1738) antibody (Atto 594)NALCN 适用: 大鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S187-7 Atto 594
anti-Sodium Leak Channel, Non-Selective (NALCN) (AA 1659-1738) antibody (Atto 390)NALCN 适用: 大鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S187-7 Atto 390
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- 应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:200
- 说明
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Negative Control: (ABIN7236886)
Blocking Peptide: (ABIN7236886)
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- 抗原
- NALCN (Sodium Leak Channel, Non-Selective (NALCN))
- 别名
- NALCN (NALCN 产品)
- 背景
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Sodium leak channel non-selective protein, Voltage gated channel-like protein 1, Four domain-type voltage-gated ion channel alpha-1 subunit, CanIon, Rb21-channel,The existence of resting K+ conductance has been known for some time. Only recently has the Nalcn (sodium leak channel non-selective protein) been found responsible for the resting Na+ conductance1.Nalcn is a member of the NaV and CaV channel family which have four homologous repeats of six transmembrane domains. One structural difference is that Nalcn is less positively charged in the voltage sensing segment1. The protein forms voltage-independent non-inactivating channel which is permeable to Na+, K+ and Ca2+ ions1,2.Evidence suggests that Nalcn is a non-redundant and thus essential channel since knock-out mice display disrupted respiratory rhythm and die within 24 hours of birth. In addition, isolated neurons from these mice have decreased excitability1.The channel is extensively expressed in the central nervous system1, heart, pituitary and adrenal glands and pancreatic islet cells2,3.In pancreatic islets, Nalcn is activated by acetylcholine via its physical association with M3 muscarinic receptor, and potentiates insulin secretion induced by glucose uptake2-4.
Alternative names: NALCN/VGCNL1, Sodium leak channel non-selective protein, Voltage gated channel-like protein 1, Four domain-type voltage-gated ion channel alpha-1 subunit, CanIon, Rb21-channel - 基因ID
- 266760
- NCBI登录号
- NM_052867
- UniProt
- Q6Q760
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