SCN3A 抗体 (Intracellular)
Quick Overview for SCN3A 抗体 (Intracellular) (ABIN7043643)
抗原
See all SCN3A 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 511-524, Intracellular
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原理
- A Rabbit Polyclonal Antibody to SCN3A (NaV1.3) Channel
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特异性
- Intracellular, loop between domains I and II
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse - 12,14 amino acid residues identical
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产品特性
- Anti-SCN3A (NaV1.3) Antibody (ABIN7043643, ABIN7045227 and ABIN7045228) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot, immunoprecipitation, and immunohistochemistry, and immunocytochemistry applications. It has been designed to recognize NaV1.3 from rat, human, and mouse samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)HLEGNHRADGDRFP, corresponding to amino acid residues 511-524 rat NaV1.3
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亚型
- IgG
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anti-Sodium Channel, Voltage-Gated, Type III, alpha Subunit (SCN3A) (AA 274-400) antibody
SCN3A 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Sodium Channel, Voltage-Gated, Type III, alpha Subunit (SCN3A) (AA 1861-1960) antibodySCN3A 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3F3 unconjugated
anti-Sodium Channel, Voltage-Gated, Type III, alpha Subunit (SCN3A) (C-Term) antibodySCN3A 适用: 人 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Sodium Channel, Voltage-Gated, Type III, alpha Subunit (SCN3A) (AA 1861-1960) antibodySCN3A 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2F8 unconjugated
anti-Sodium Channel, Voltage-Gated, Type III, alpha Subunit (SCN3A) (AA 277-288), (Extracellular) antibodySCN3A 适用: 大鼠 WB, IF, IC, LCI 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:100
Application Dilutions Western blot wb: 1:200
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说明
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Cited Application: IHC
Negative Control: (ABIN7236843)
Blocking Peptide: (ABIN7236843)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- SCN3A (Sodium Channel, Voltage-Gated, Type III, alpha Subunit (SCN3A))
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别名
- SCN3A
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背景
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BIII, Brain type III Na+ channel, Sodium channel protein type 3 subunit alpha,Voltage-gated sodium channels (NaV) are essential for the generation of action potentials and for cell excitability.1 NaV channels are activated in response to depolarization and selectively allow flow of Na+ ions. To date, nine NaV α subunits have been cloned and named NaV1.1-NaV1.9.4-5 The NaV channels are classified into two groups according to their sensitivity to Tetrodotoxin (TTX): TTX-sensitive (NaV1.1, NaV1.2, NaV1.3, NaV1.4, NaV1.6 and NaV1.7) and TTX-resistant (NaV1.5, NaV1.8 and NaV1.9).2-3Mammalian sodium channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β subunits. The expression of the α subunit isoform is developmentally regulated and tissue specific. Sodium channels in the adult central nervous system and heart contain β1 through β4 subunits, whereas sodium channels in adult skeletal muscle have only the β1 subunit.6,7NaV1.3, also known as SCN3A, is highly expressed in embryonic sensory neurons and CNS, but its level dramatically decreases in adult rodents.8 Up-regulation of NaV1.3 channel expression was described in injured neurons and injured spinal cord.9-11
Alternative names: SCN3A (NaV1.3), BIII, Brain type III Na+ channel, Sodium channel protein type 3 subunit alpha -
基因ID
- 497770
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NCBI登录号
- NM_006922
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UniProt
- P08104
抗原
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