Serotonin Receptor 4 抗体 (Extracellular)
Quick Overview for Serotonin Receptor 4 抗体 (Extracellular) (ABIN7043624)
抗原
See all Serotonin Receptor 4 (HTR4) 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- AA 168-180, Extracellular
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原理
- A Rabbit Polyclonal Antibody to 5-Hydroxytryptamine Receptor 4
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特异性
- 2nd extracellular loop
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse - 12,13 amino acid residues identical, human - 11
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产品特性
- Anti-5HT4 Receptor (HTR4) (extracellular) Antibody (ABIN7043624, ABIN7045290 and ABIN7045291) is a highly specific antibody directed against an epitope of the rat Serotonin receptor 4. The antibody can be used in western blot, immunocytochemistry, and live cell imaging applications. It has been designed to recognize 5HT4 receptor from rat, mouse, and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)DVIEKRKFNHNSN, corresponding to amino acid residues 168-180 of rat 5-Hydroxytryptamine receptor 4
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亚型
- IgG
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anti-Serotonin Receptor 4 (HTR4) (AA 316-388) antibody
HTR4 适用: 人 ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 4 (HTR4) (Cytoplasmic Domain) antibodyHTR4 适用: 人, Cow, Pig, 犬, 马, 兔, 猴, Bat IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 4 (HTR4) (C-Term) antibodyHTR4 适用: 人, 大鼠, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 4 (HTR4) (AA 21-120) antibodyHTR4 适用: 大鼠, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 4 (HTR4) (N-Term) antibodyHTR4 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 4 (HTR4) (C-Term) antibodyHTR4 适用: 人, Pig, 马, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 4 (HTR4) (C-Term) antibodyHTR4 适用: 人, Cow, 犬, 马, 豚鼠, 兔, Bat, Hamster IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 4 (HTR4) (AA 144-193) antibodyHTR4 适用: 人, 大鼠, Cow, 犬, 豚鼠, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 4 (HTR4) (Middle Region) antibodyHTR4 适用: 人, 大鼠, 小鼠, Cow, Pig, 犬 WB 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 4 (HTR4) (AA 21-70) antibodyHTR4 适用: 人, 大鼠, 小鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:200
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- Serotonin Receptor 4 (HTR4)
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别名
- HTR4
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背景
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5-Hydroxytryptamine receptor 4, Serotonin receptor 4,5-hydroxytryptamine receptor 4 (5-HT4 receptors) are a subclass among the large family of receptors mediating serotonin actions at central and peripheral targets. 5-HT4 receptor activation has been implicated in learning and memory, feeding control and stress response. 5-HT4 receptors are encoded by a complex gene which in humans, generates ten different splice variants1, 2.The 5-HT4 receptor, a member of the seven transmembrane spanning G-protein-coupled receptors (GPCRs), couples via Gs to increase cAMP production. GPCRs share a similar topology, with seven transmembrane helices (TMHs) connected by three extracellular loops (ECLs), and three intracellular loops (ICLs), the N-terminus is on the extracellular side of the membrane, and the C-terminus is on the cytoplasmic side3.Within the central nervous system, these receptors are expressed in limbic structures including: hypothalamus, nucleus accumbens, prefrontal cortex, amygdala and hippocampus, where they contribute to emotional and cognitive functions4.Low levels of 5-HT4 receptors are associated with numerous neuropsychiatric disorders including Alzheimer's disease, Huntington's disease, feeding disorders and stress-related disorders such as anxiety and depression5.
Alternative names: 5HT4 Receptor (HTR4), 5-Hydroxytryptamine receptor 4, Serotonin receptor 4 -
基因ID
- 25324
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NCBI登录号
- NM_000870
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UniProt
- Q62758
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途径
- JAK/STAT Signaling, cAMP Metabolic Process, S100 Proteins
抗原
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