Serotonin Receptor 3B 抗体 (Extracellular, N-Term)
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Quick Overview for Serotonin Receptor 3B 抗体 (Extracellular, N-Term) (ABIN7043622)
抗原
See all Serotonin Receptor 3B (HTR3B) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 213-226, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to 5-Hydroxytryptamine Receptor 3B
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交叉反应
- 小鼠, 大鼠
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预测反应
- Mouse - identicalHuman- not recommended for use with human samples
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产品特性
- Anti-5HT3B Receptor (HTR3B) (extracellular) Antibody (ABIN7043622 and ABIN7045285) is a highly specific antibody directed against an epitope of rat Serotonin receptor 3B. The antibody can be used in western blot and immunohistochemistry applications. It recognizes an extracellular epitope and can potentially detect 5-HT3B in living cells. It has been designed to recognize 5-HT3B from rat and mouse samples. The antibody is unlikely to recognize the receptor from human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)HIRQSSAGDFAQIR, corresponding to amino acid residues 213-226 of rat 5-Hydroxytryptamine receptor 3B
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亚型
- IgG
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anti-Serotonin Receptor 3B (HTR3B) (AA 23-150) antibody
HTR3B 适用: 人 WB, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 2H9H5 unconjugated
anti-Serotonin Receptor 3B (HTR3B) (AA 23-150) antibodyHTR3B 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4G6H7 unconjugated
anti-Serotonin Receptor 3B (HTR3B) (AA 22-238) antibodyHTR3B 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 3B (HTR3B) (AA 101-200) antibodyHTR3B 适用: 人, 大鼠 WB, ELISA, FACS, IF (cc), IF (p), IHC (fro), IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 3B (HTR3B) (N-Term) antibodyHTR3B 适用: 人, 大鼠, Cow, 豚鼠, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 3B (HTR3B) (N-Term) antibodyHTR3B 适用: 人, 大鼠, 小鼠, Cow, 豚鼠, Pig, 犬, 兔 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 3B (HTR3B) (AA 1-441) antibodyHTR3B 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Serotonin Receptor 3B (HTR3B) (Internal Region) antibodyVerified HTR3B 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Serotonin Receptor 3B (HTR3B) (Internal Region) antibodyVerified HTR3B 适用: 大鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Serotonin Receptor 3B (HTR3B) (C-Term) antibodyHTR3B 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- Serotonin Receptor 3B (HTR3B)
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别名
- HTR3B
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背景
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Synonyms: 5-Hydroxytryptamine receptor 3B, Serotonin receptor 3B
Description: 5-Hydroxytryptamine receptor 3B (5-HT3B, HTR3B) belongs to the superfamily of ligand-gated ion channels. Serotonin receptors, other than the 5-HT3 subtype, belong to the superfamily of G-protein coupled receptors.The 5-HT3 receptor is formed by five subunits arranged around a pore forming unit. Receptors could be either monomeric, such as 5-HT3A or heteromeric entities like 5-HT3A/B. Indeed, the type of channel formed displays different pharmacological and electrophysiological characteristics1,2. To date, five 5-HT3 subunits have been identified and labeled 5-HT3A-E, which show variability in the N-terminus and in the transmembrane region2. 5-HT3A and 5-HT3B are the best characterized among the different types.In general, 5-HT3 receptors are located in the peripheral and central nervous system, in lymphocytes and intestinal enterochromaffine cells2. In presynaptic neurons, activation of these receptors leads to an increase in intracellular Ca2+ (by both influx and mobilization of intracellular stores), and modulates the release of a number of neurotransmitters and neuropeptides2. At the postsynaptic level, activation leads to membrane depolarization2,3. The localization of 5-HT3B subunits is somewhat controversial, some studies show that its expression is restricted to the peripheral nervous system and others show that it is also detected in the brain and in hippocampal neurons1,4-7.5-HT3 receptors have become important targets for which to develop treatments for irritable bowel syndrome (IBS), side effects resulting from chemotherapeutic treatment, schizophrenia and bipolar disorder1,2.
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基因ID
- 58963
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NCBI登录号
- NM_006028
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UniProt
- Q9JJ16
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途径
- Synaptic Membrane
抗原
-
