5HT1D 抗体 (Extracellular, N-Term)
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Quick Overview for 5HT1D 抗体 (Extracellular, N-Term) (ABIN7043618)
抗原
See all 5HT1D (HTR1D) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 14-27, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to 5-Hydroxytryptamine Receptor 1D
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交叉反应
- 人, 大鼠
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预测反应
- Mouse - identical, human - 13,14 amino acid residues identical
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产品特性
- Anti-5HT1D Receptor (HTR1D) (extracellular) Antibody is directed against an extracellular epitope of the rat 5-Hydroxytryptamine receptor 1D. Anti-5HT1D Receptor (HTR1D) (extracellular) Antibody (ABIN7043618 and ABIN7045282) can be used in western blot analysis. It has been designed to recognize 5HT1D receptor from human, rat and mouse samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)EASNRSLNATGAWD, corresponding to amino acid residues 14-27 of rat 5-hydroxytryptamine receptor 1D
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亚型
- IgG
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anti-Serotonin Receptor 1D (HTR1D) antibody
HTR1D 适用: 小鼠, 人, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 1D (HTR1D) (Cytoplasmic Domain) antibodyHTR1D 适用: 人, Pig IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 1D (HTR1D) (Cytoplasmic Domain) antibodyHTR1D 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 1D (HTR1D) (Internal Region) antibodyHTR1D 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 1D (HTR1D) (AA 150-250) antibodyHTR1D 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 1D (HTR1D) (AA 272-301), (C-Term) antibodyHTR1D 适用: 小鼠 WB 宿主: 兔 Polyclonal RB39337 unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:300
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7236788)
Blocking Peptide: (ABIN7236788)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- 5HT1D (HTR1D) (Serotonin Receptor 1D (HTR1D))
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别名
- HTR1D
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背景
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Synonyms: 5-Hydroxytryptamine receptor 1D, Serotonin receptor 1D, 5HT1D-alpha, HTR1DA
Description: Serotonin (5-hydroxytryptamine, 5-HT) plays unequivocally a most important role in the normal physiology amongst higher eukaryotes, as do most neurotransmitters. The physiological roles of serotonin and its receptors range from appetite, regulation of the circadian rhythm, sexual behavior, memory and nociception. Serotonin is also involved in migraine and some psychiatric diseases such as depression anxiety and aggression1. Serotonin and its receptors also have an influence on the cardiovascular, pulmonary, gastrointestinal (GI) and genitourinary systems2.To date, some fifteen serotonin receptors have been cloned and grouped into seven families (5-HT1-5-HT7) based on their signaling mechanisms. The 5-HT1 receptor class comprises 5 different receptors with ranging homology. Apart from 5-HT3, all serotonin receptors belong to the G-protein coupled receptor superfamily and therefore span the membrane seven times3.Members of the 5-HT1 receptor class all couple Gi/0 thereby inhibiting adenylate cyclase.In the central nervous system, 5-HT1D is expressed in the basal ganglia, hippocampus and cortex in the rat and in the basal ganglia, midbrain and spinal cord in the human. In serotonin neurons, 5-HT1D receptors are autoreceptors thereby inhibiting the release of 5-HT. In GABA, ACh, and glutamate neurons they are heteroreceptors where they control the release of these neurotransmitters4,5.The serotonin system plays an undeniable role in the perception and processing of pain. Indeed, many migraine sufferers are prescribed triptan-based drugs which activate 5-HT1B and 5-HT1D receptors2.
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基因ID
- 25323
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NCBI登录号
- NM_000864
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UniProt
- P28565
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途径
- JAK/STAT Signaling
抗原
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