5HT1B Receptor 抗体 (Extracellular, N-Term)
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Quick Overview for 5HT1B Receptor 抗体 (Extracellular, N-Term) (ABIN7043616)
抗原
See all 5HT1B Receptor (HTR1B) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 33-49, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to 5-Hydroxytryptamine Receptor 1B
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Rat - 15,17 amino acid residues identical, mouse - 14
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产品特性
- Anti-5HT1B Receptor (HTR1B) (extracellular) Antibody (ABIN7043616, ABIN7045280 and ABIN7045281) is a highly specific antibody directed against an epitope of the human 5-Hydroxytryptamine receptor 1B. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize 5HT1B receptor from human, rat, and mouse samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- CSAKDYIYQDSISLPWK, corresponding to amino acid residues 33-49 of human 5-Hydroxytryptamine receptor 1B
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亚型
- IgG
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anti-Serotonin Receptor 1B (HTR1B) (Internal Region) antibody
HTR1B 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 1B (HTR1B) (Internal Region) antibodyHTR1B 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 1B (HTR1B) (AA 35-390) antibodyHTR1B 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 1B (HTR1B) (C-Term) antibodyVerified HTR1B 适用: 人, 小鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Serotonin Receptor 1B (HTR1B) (AA 1-49) antibodyHTR1B 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Serotonin Receptor 1B (HTR1B) (Cytoplasmic Domain) antibodyHTR1B 适用: 人, 大鼠, 小鼠, 犬, Bat, Cow, 豚鼠, Hamster, 兔, Pig IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 1B (HTR1B) (N-Term) antibodyHTR1B 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 1B (HTR1B) (AA 8-26) antibodyHTR1B 适用: 人, 大鼠, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 1B (HTR1B) (N-Term) antibodyHTR1B 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:400
FC: 2.5 mg per reaction
ICC: The optimal concentration should be determined by the user
IHC: 1:200
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7236784)
Blocking Peptide: (ABIN7236784)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- 5HT1B Receptor (HTR1B) (Serotonin Receptor 1B (HTR1B))
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别名
- HTR1B
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背景
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Synonyms: 5-Hydroxytryptamine receptor 1B, Serotonin receptor 1B, Serotonin 1D beta receptor, 5HT1D-beta, HTR1DB, HTR1D2
Description: Serotonin (5-hydroxytryptamine, 5-HT) plays unequivocally a most important role in the normal physiology amongst higher eukaryotes, as do most neurotransmitters. The physiological roles of serotonin and its receptors range from appetite, regulation of the circadian rhythm, sexual behavior, memory and nociception. Serotonin is also involved in migraine and some psychiatric diseases such as depression anxiety and aggression1. Serotonin and its receptors also have an influence on the cardiovascular, pulmonary, gastrointestinal (GI) and genitourinary systems2.To date, some fifteen serotonin receptors have been cloned and grouped into seven families (5-HT1-5-HT7) based on their signaling mechanisms. The 5-HT1 receptor class comprises 5 different receptors with ranging homology. Apart from 5-HT3, all serotonin receptors belong to the G-protein coupled receptor superfamily and therefore span the membrane seven times3.The 5-hydroxytryptamine receptor 1B (5-HT1B) is involved in several physiological behaviors and psychiatric diseases, including locomotor activity, drug abuse reinforcement, migraine, anxiety states and aggressive behaviors1.Pharmacological studies suggest that 5-HT1B is expressed by both serotonergic and non-serotonergic neurons. In the nervous system, this receptor is located in the axon terminal of the plasma membrane of unmyelinated axons. It is predominantly localized on pre-synaptic membranes. Signal transduction studies of the receptor indicate that this receptor is coupled negatively to adenylyl cyclase as its activation induces a decrease in adenylyl cyclase activity1.
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基因ID
- 3351
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NCBI登录号
- NM_000863
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UniProt
- P28222
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途径
- JAK/STAT Signaling, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Feeding Behaviour, S100 Proteins
抗原
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