SCTR 抗体 (Extracellular)
Quick Overview for SCTR 抗体 (Extracellular) (ABIN7043607)
抗原
See all SCTR 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 129-143, Extracellular
-
原理
- A Rabbit Polyclonal Antibody to Secretin Receptor
-
特异性
- Extracellular, N-terminus
-
交叉反应
- 人, 小鼠, 大鼠
-
预测反应
- 15 amino acid residues identical,Mouse - 14, human - 12
-
产品特性
- Anti-Secretin Receptor (extracellular) Antibody (ABIN7043607, ABIN7044414 and ABIN7044415) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize SCTR from human, mouse, and rat samples.
-
纯化方法
- Affinity purified on immobilized antigen.
-
免疫原
-
Immunogen: Synthetic peptide
Immunogen Sequence: Peptide (C)NSFNERRHAYLLKLK, corresponding to amino acid residues 129 - 143 of rat Secretin Receptor
-
亚型
- IgG
-
-
anti-Secretin Receptor (SCTR) (AA 51-135) antibody
SCTR 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Secretin Receptor (SCTR) (AA 32-141) antibodySCTR 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3H1 unconjugated
anti-Secretin Receptor (SCTR) (Internal Region) antibodySCTR 适用: 人 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Secretin Receptor (SCTR) (AA 188-280) antibodySCTR 适用: 小鼠 WB, ELISA, IF (cc), IF (p), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200
Application Dilutions Western blot wb: 1:200
-
说明
-
Negative Control: (ABIN7236749)
Blocking Peptide: (ABIN7236749)
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
-
浓度
- 1 mg/mL
-
缓冲液
- PBS pH 7.4
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
-
-
- SCTR (Secretin Receptor (SCTR))
-
别名
- SCTR
-
背景
-
SCTR,Secretin receptor, SCTR, binds Secretin, a hormone that affects water homeostasis throughout the body and specifically in the duodenum of the small intestine.SCTR is ubiquitously expressed throughout the body. It belongs to class B1 of G-protein coupled receptors, along with vasoactive intestinal polypeptide (VIP) receptor. Like all G-protein coupled receptors, it is composed of seven highly conserved transmembrane domains1. The amino terminus of Secretin receptor plays a key role in agonist recognition and responsiveness2.The binding of SCTR to Secretin initiates a signaling cascade that stimulates bicarbonate secretion which in turn leads to neutralization of gastric H+. This process plays an essential role in fat digestion by creating a more neutral ( pH 6 to 8) environment. Secretin levels are regulated by H+ and fatty acids levels in the duodenum and hence the secretion regulation is tightly bound to its activity3.In addition, SCTR-Secretin interaction plays a major role in the regulation of the secretory activity in the heart, liver and the central nervous system (CNS)3.
Alternative names: SCTR, Secretin Receptor -
基因ID
- 6344
-
NCBI登录号
- NM_002980
-
UniProt
- P23811
抗原
-
