RYR2 抗体 (Intracellular, N-Term)
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Quick Overview for RYR2 抗体 (Intracellular, N-Term) (ABIN7043605)
抗原
See all RYR2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1489-1502, Intracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to Ryanodine Receptor 2
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Rat,mouse - identical
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产品特性
- Anti-Ryanodine Receptor 2 Antibody (ABIN7043605, ABIN7045213 and ABIN7045214) is a highly specific antibody directed against an epitope of human RyR2. The antibody can be used in western blot, immunocytochemistry, and immunohistochemistry applications. It has been designed to recognize RyR2 from human, rat, and mouse samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- CAGESMSPGQGRNN, corresponding to amino acid residues 1489-1502 of human RyR2
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亚型
- IgG
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anti-Ryanodine Receptor 2 (Cardiac) (RYR2) (AA 901-1192) antibody
RYR2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ryanodine Receptor 2 (Cardiac) (RYR2) (AA 4850-4950) antibodyRYR2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Ryanodine Receptor 2 (Cardiac) (RYR2) (pSer2808) antibodyRYR2 适用: 人, 小鼠, 大鼠, 兔 IHC, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Ryanodine Receptor 2 (Cardiac) (RYR2) (Tyr1018) antibodyRYR2 适用: 人, 小鼠, 大鼠 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ryanodine Receptor 2 (Cardiac) (RYR2) antibodyRYR2 适用: 人, 小鼠, 大鼠 ELISA, WB, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ryanodine Receptor 2 (Cardiac) (RYR2) antibodyRYR2 适用: 人, 小鼠, 大鼠 ELISA, IHC, WB, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:50-1:100
IP: The optimal concentration should be determined by the user
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说明
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Cited Application: IP|IHC|ICC
Negative Control: (ABIN7236742)
Blocking Peptide: (ABIN7236742)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- RYR2 (Ryanodine Receptor 2 (Cardiac) (RYR2))
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别名
- RYR2
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背景
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Synonyms: RyR2, Cardiac muscle ryanodine receptor
Description: It is well established that cytosolic calcium (Ca2+) acts as a key second messenger in many intracellular pathways including synaptic transmission, muscle contraction, hormonal secretion, cell growth and proliferation.1,2 The primary intracellular Ca2+ storage/release organelle in most cells is the endoplasmic reticulum (ER) or the sarcoplasmic reticulum (SR) in striated muscle cells.The ER and SR contain two Ca2+ release channel families, the inositol trisphosphate receptors (IP3Rs) and the ryanodine receptors (RyRs).3The ryanodine receptor family consists of three different isoforms: the skeletal muscle isoform, ryanodine receptor type 1 (RyR1), the cardiac muscle isoform, ryanodine receptor type 2 (RyR2) and the brain isoform, ryanodine receptor type 3 (RyR3).3The ryanodine receptors are homotetrameric proteins, which upon assembly create a Ca2+ conducting channel. They play a key role in the mechanism of excitation-contraction coupling in striated muscle. Binding of ryanodine (a poisonous alkaloid found in the South American plant Ryania speciosa) to the ryanodine receptor causes two major changes in the channel: a reduction in single-channel conductance and a marked increase in the open state probability, leading to an overall increase/decrease in the Ca2+ release capability of the channel.RyR2 serves as an intracellular Ca2+ channel in the SR membrane. It is predominantly expressed in cardiac muscle where it plays a central role in cardiac excitation-contraction coupling. RyR2 is also expressed in the brain.1-4
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基因ID
- 6262
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NCBI登录号
- NM_001035
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UniProt
- Q92736
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途径
- Myometrial Relaxation and Contraction
抗原
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