RTN4R 抗体 (Extracellular)
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- 抗原 See all RTN4R 抗体
- RTN4R (Reticulon 4 Receptor (RTN4R))
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抗原表位
- AA 366-381, Extracellular
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This RTN4R antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (IF), Immunochromatography (IC), Live Cell Imaging (LCI)
- 原理
- A Rabbit Polyclonal Antibody to Nogo Receptor
- 特异性
- Extracellular
- 交叉反应
- 人, 小鼠, 大鼠
- 预测反应
- Mouse,rat - 15,16 amino acid residues identical
- 产品特性
- Anti-Nogo Receptor (extracellular) Antibody is directed against an extracellular epitope of the human Nogo receptor. Anti-Nogo Receptor (extracellular) Antibody (ABIN7043601, ABIN7044757 and ABIN7044758) can be used in western blot, immunohistochemistry and live cell imaging applications. It has been designed to recognize NgR from human, mouse and rat samples.
- 纯化方法
- Affinity purified on immobilized antigen.
- 免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)GDSPPGNGSGPRHIND corresponding to amino acid residues 366-381 of the human Nogo receptor
- 亚型
- IgG
- Top Product
- Discover our top product RTN4R Primary Antibody
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anti-Reticulon 4 Receptor (RTN4R) (AA 151-350) antibody
RTN4R 适用: 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Reticulon 4 Receptor (RTN4R) antibodyRTN4R 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Reticulon 4 Receptor (RTN4R) (AA 1-473) antibodyRTN4R 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Reticulon 4 Receptor (RTN4R) (AA 244-473) antibodyRTN4R 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Reticulon 4 Receptor (RTN4R) (AA 1-473) antibodyRTN4R 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Reticulon 4 Receptor (RTN4R) (Internal Region) antibodyVerified RTN4R 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Reticulon 4 Receptor (RTN4R) antibodyRTN4R 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Reticulon 4 Receptor (RTN4R) (AA 366-381), (Extracellular) antibody (FITC)RTN4R 适用: 人 FACS 宿主: 兔 Polyclonal FITC
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- 应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:200
- 说明
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Cited Application: IHC
Negative Control: (ABIN7236730)
Blocking Peptide: (ABIN7236730)
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
- 浓度
- 1 mg/mL
- 缓冲液
- PBS pH 7.4
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- 抗原
- RTN4R (Reticulon 4 Receptor (RTN4R))
- 别名
- RTN4R (RTN4R 产品)
- 背景
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NogoR, Nogo-R, NgR, NgR1, Nogo-66 receptor, Reticulon 4 receptor, RTN4R,The Nogo receptor is a leucine-rich repeat (LRR) containing protein with a glycosylphosphatidylinositol (GPI) anchored C-terminus. The receptor was identified on the basis of its ability to bind with high affinity to Nogo-A a member of the reticulon family expressed in the cell membrane of oligodendrocytes.1Nogo-A attracted attention when it was demonstrated that it is a myelin protein capable of inhibiting axonal growth following nerve injury.2,3 Other myelin proteins also identified as axonal growth inhibitors are the myelin-associated glycoprotein (MAG) a sialic-dependent immunoglobulin-like family member lectin (SIGLEC) and the oligodendrocyte myelin glycoprotein (OmgP) which is a GPI-anchored membrane protein. Remarkably, despite their structural diversity, all three axonal growth inhibitors bind to the Nogo receptor with high affinity.4,5Since the Nogo receptor is a GPI-anchored protein it was expected that it would require another protein component to transduce the Nogo-A binding information into the responding neurons interior. Indeed, it was shown that the neurotrophin receptor p75 (p75NTR) interacts with Nogo receptor and a third protein termed LINGO-1 to mediate axonal growth inhibition signaling.6,7
Alternative names: Nogo Receptor, NogoR, Nogo-R, NgR, NgR1, Nogo-66 receptor, Reticulon 4 receptor, RTN4R - 基因ID
- 65078
- NCBI登录号
- NM_023004
- UniProt
- Q9BZR6
- 途径
- Neurotrophin Signaling Pathway
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