RXFP2 抗体 (Extracellular)
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Quick Overview for RXFP2 抗体 (Extracellular) (ABIN7043598)
抗原
See all RXFP2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 556-570, Extracellular
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原理
- A Rabbit Polyclonal Antibody to Relaxin Receptor 2
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特异性
- 2nd extracellular loop
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交叉反应
- 小鼠, 大鼠
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交叉反应 （详细）
- Not recommended for use on human samples.
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预测反应
- Rat - identical
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产品特性
- Anti-RXFP2 (extracellular) Antibody is directed against an epitope of the rat Relaxin receptor 2. Anti-RXFP2 (extracellular) Antibody (ABIN7043598, ABIN7045217 and ABIN7045218) can be used in western blot analysis. The antibody recognizes an extracellular epitope and is thus ideal for detecting the receptor in living cells. It has been designed to recognize Relaxin receptor 2 from mouse and rat samples. The antibody is unlikely to recognize human RXFP2.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: CFPLHYDQAEDFGSR, corresponding to amino acid residues 556-570 of mouse RXFP2
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亚型
- IgG
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anti-Relaxin/insulin-Like Family Peptide Receptor 2 (RXFP2) (AA 33-158) antibody
RXFP2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Relaxin/insulin-Like Family Peptide Receptor 2 (RXFP2) (N-Term) antibodyRXFP2 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Relaxin/insulin-Like Family Peptide Receptor 2 (RXFP2) (Cytoplasmic Domain) antibodyRXFP2 适用: 人, 小鼠, 马 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Relaxin/insulin-Like Family Peptide Receptor 2 (RXFP2) (Extracellular Domain) antibodyRXFP2 适用: 人, 小鼠 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Relaxin/insulin-Like Family Peptide Receptor 2 (RXFP2) (Internal Region) antibodyRXFP2 适用: 人, 小鼠, 大鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:400
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说明
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Negative Control: (ABIN7236718)
Blocking Peptide: (ABIN7236718)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- RXFP2 (Relaxin/insulin-Like Family Peptide Receptor 2 (RXFP2))
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别名
- RXFP2
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背景
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Relaxin receptor 2, G-protein coupled receptor affecting testicular descent, Leucine-rich repeat-containing G-protein coupled receptor 8, GPR106, GREAT, LGR8, INSL3R,Relaxin (RXFP) peptides are members of a family of peptide hormones, structurally related to insulin, which act on a group of four G-protein-coupled receptors known as Relaxin family peptide receptors (RXFPs): RXFP1-4.The RXFP2 (also called LGR8) structure contains 7-transmemebrane spanning domains, at least two binding sites: a long extracellular sequence with a high affinity site containing 10 leucine-rich repeat region and a lower-affinity site in an extracellular loop of a transmembrane region. In addition, the receptor contains an N-terminal ectodomain that acts as a site of primary ligand binding1,2. RXFP2 is also the native receptor for insulin-like peptide 3 (INSL3)1,2. Activation of the receptor leads to increased levels of cAMP.In human, RXFP2 can be detected in the uterus, testis, kidney, brain, thyroid, muscle, peripheral blood cells and bone marrow. Additional expression in rat and mouse was detected in the ovary and gubernaculums. Studies show that activators of RXFP2 may play an important role in the treatment of cryptorchidism and infertility and RXFP2 inhibitors could be used as a means of contraception1. RXFP2 also was found to cause the failure of gubernacular development during embryogenesis in human and mouse3.
Alternative names: RXFP2, Relaxin receptor 2, G-protein coupled receptor affecting testicular descent, Leucine-rich repeat-containing G-protein coupled receptor 8, GPR106, GREAT, LGR8, INSL3R -
基因ID
- 140498
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NCBI登录号
- NM_130806
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UniProt
- Q91ZZ5
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途径
- cAMP Metabolic Process, Myometrial Relaxation and Contraction
抗原
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