QRFPR 抗体 (Extracellular)
Quick Overview for QRFPR 抗体 (Extracellular) (ABIN7043594)
抗原
See all QRFPR 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 18-32, Extracellular
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原理
- A Rabbit Polyclonal Antibody to QRFP Receptor
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特异性
- Extracellular, N-terminus
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse - identical, human - 13,17 amino acid residues identical
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产品特性
- Anti-QRFPR/GPR103 (extracellular) Antibody (ABIN7043594, ABIN7044421 and ABIN7044422) is a highly specific antibody directed against an epitope of the rat QRFP receptor. The antibody can be used in western blot analysis. The antibody recognizes an extracellular epitope and can potentially be used for detecting the receptor in living cells. It has been designed to recognize GPCR GPR103 from rat, mouse, and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)HNLTREQFIHRYGLR, corresponding to amino acid residues 18-32 of rat QRFP receptor
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亚型
- IgG
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anti-Pyroglutamylated RFamide Peptide Receptor (QRFPR) (Internal Region) antibody
QRFPR 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Pyroglutamylated RFamide Peptide Receptor (QRFPR) (Cytoplasmic Domain) antibodyQRFPR 适用: 人 IHC (p), IHC 宿主: 兔 Polyclonal unconjugated
anti-Pyroglutamylated RFamide Peptide Receptor (QRFPR) (N-Term) antibodyQRFPR 适用: 人, Cow, 马, 兔, Pig IHC (p), IHC 宿主: 兔 Polyclonal unconjugated
anti-Pyroglutamylated RFamide Peptide Receptor (QRFPR) (AA 151-250) antibodyQRFPR 适用: 人 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Pyroglutamylated RFamide Peptide Receptor (QRFPR) (AA 271-320) antibodyQRFPR 适用: 人, 小鼠, 大鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:500
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说明
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Negative Control: (ABIN7236703)
Blocking Peptide: (ABIN7236703)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- QRFPR (Pyroglutamylated RFamide Peptide Receptor (QRFPR))
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别名
- QRFPR
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背景
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Pyroglutamylated RF-amide peptide receptor, Orexigenic neuropeptide QRFP receptor, G-protein coupled receptor 103, Peptide P518 receptor, SP9155, AQ27,QRFP is a 26-amino acid peptide (QRFP-26) that, widely distributed among vertebrates, is a member of the RF amide peptide family harboring the arginine-phenylalanine-amide (Arg-Phe-NH2) sequence motif in their carboxyl terminal. It is the cognate ligand of the human orphan receptor GPR103, a G protein-coupled receptor. Like other members of the super family, QRFP receptor has an extracellular N-terminal tail and intracellular C-terminus.Its QRFP N-terminus binds with high affinity to GPR103 and has the efficacy to inhibit cAMP synthesis. QRFP has been shown to affect locomotor activity, energy homeostasis, reproduction, bone formation, blood pressure, hormone regulation, nociception, and appetite stimulation.QRFP expressing neurons have shown to be expressed in various hypothalamic nuclei including the ventromedial hypothalamic nucleus, the lateral hypothalamic area, retrochiasmatic area and the arcuate nucleus1,2. The receptor is detected in the CNS and in peripheral tissues, notably in bone, heart, kidney, pancreas and testis.Increasing data suggest the ligand/receptor system plays an important role in the regulation of food intake and glucose homeostasis1.
Alternative names: QRFPR/GPR103, Pyroglutamylated RF-amide peptide receptor, Orexigenic neuropeptide QRFP receptor, G-protein coupled receptor 103, Peptide P518 receptor, SP9155, AQ27 -
基因ID
- 310327
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NCBI登录号
- NM_198179
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UniProt
- P83858
抗原
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