KCNH1 抗体 (Intracellular)
Quick Overview for KCNH1 抗体 (Intracellular) (ABIN7043542)
抗原
See all KCNH1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 802-817, Intracellular
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原理
- A Rabbit Polyclonal Antibody to KV10.1 Channel
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特异性
- Intracellular, C-terminus
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交叉反应
- 人, 小鼠, 大鼠
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交叉反应 （详细）
- The antibody is specific for KV10.1 and will not cross-react with KV10.2.
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预测反应
- Mouse - identical, human -14,16 amino acid residues identical
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产品特性
- Anti-KCNH1 Antibody is directed against an intracellular epitope of the rat KV10.1 channel. Anti-KCNH1 Antibody (ABIN7043542, ABIN7044998 and ABIN7044999) can be used in western blot, immunoprecipitation, immunohistochemistry, and immunocytochemistry applications. It has been designed to recognize KV10.1 from rat, human, and mouse samples. The antibody is specific for KV10.1 and will not cross-react with KV10.2.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: GDPAKRKGWARFKDAC, corresponding to amino acid residues 802-817 of rat KCNH1
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亚型
- IgG
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anti-Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 1 (KCNH1) (AA 787-820) antibody
KCNH1 适用: 人 WB, FACS, IF 宿主: 兔 Polyclonal RB57957 unconjugated
anti-Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 1 (KCNH1) (AA 890-988) antibodyKCNH1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 1 (KCNH1) antibodyKCNH1 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 1 (KCNH1) (AA 840-989) antibodyKCNH1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 1 (KCNH1) (C-Term) antibodyKCNH1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 1 (KCNH1) (Internal Region) antibodyKCNH1 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 1 (KCNH1) (AA 813-962) antibodyKCNH1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:200
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说明
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Negative Control: (ABIN7236558)
Blocking Peptide: (ABIN7236558)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- KCNH1 (Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 1 (KCNH1))
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别名
- KCNH1
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背景
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KV10.1, Ether-a-go-go potassium channel 1, hEAG1,KV10.1 is a member of the Ether-a-go-go family of voltage-activated potassium channels. To date, the family includes eight members: the closely related KV10.2 (EAG-2) protein, the KV12 (elk) (elk1, elk2, elk3) and the KV11 (erg) proteins (erg1, erg2, erg3). As with the other KV superfamily members, KV10.1 shows the characteristic 6 transmembrane domains with intracelullar N- and C-termini.The KV10 subfamily current is characterized by outward rectification without inactivation and slow activation kinetics. Its expression is normally confined to the brain where its physiological function has not yet been clarified.Intriguingly, the KV10.1 channel has been implicated in malignant tumor development. It has been shown that KV10.1 was inappropriately expressed in several cancer cell lines. Moreover, one study showed that KV10.1 by itself had oncogenic potential, as a cell line transfected with the channel, induced aggressive and faster tumor growth in vivo as compared to a cell line transfected with an unrelated KV channel.
Alternative names: KCNH1 (EAG-1), KV10.1, Ether-a-go-go potassium channel 1, hEAG1 -
基因ID
- 65198
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NCBI登录号
- NM_002238
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UniProt
- Q63472
抗原
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